A natural herbal remedy modulates angiogenic activity of bronchoalveolar lavage cells from sarcoidosis patients

Radomska-Leśniewska D, Skopińska-Różewska E, Demkow U, Jóźwiak J, Sobiecka M, Bałan B. A natural herbal remedy modulates angiogenic activity of bronchoalveolar lavage cells from sarcoidosis patients. Central European Journal of Immunology. 2016;41(1):25-30. doi:10.5114/ceji.2016.58311.

APA

Radomska-Leśniewska, D., Skopińska-Różewska, E., Demkow, U., Jóźwiak, J., Sobiecka, M.,  & Bałan, B. (2016). A natural herbal remedy modulates angiogenic activity of bronchoalveolar lavage cells from sarcoidosis patients. Central European Journal of Immunology, 41(1), 25-30. https://doi.org/10.5114/ceji.2016.58311

Chicago

Radomska-Leśniewska, Dorota M., Ewa Skopińska-Różewska, Urszula Demkow, Jarosław Jóźwiak, Małgorzata Sobiecka,  and Barbara Joanna Bałan. 2016. "A natural herbal remedy modulates angiogenic activity of bronchoalveolar lavage cells from sarcoidosis patients". Central European Journal of Immunology 41 (1): 25-30. doi:10.5114/ceji.2016.58311.

Harvard

Radomska-Leśniewska, D., Skopińska-Różewska, E., Demkow, U., Jóźwiak, J., Sobiecka, M.,  and Bałan, B. (2016). A natural herbal remedy modulates angiogenic activity of bronchoalveolar lavage cells from sarcoidosis patients. Central European Journal of Immunology, 41(1), pp.25-30. https://doi.org/10.5114/ceji.2016.58311

MLA

Radomska-Leśniewska, Dorota M. et al. "A natural herbal remedy modulates angiogenic activity of bronchoalveolar lavage cells from sarcoidosis patients." Central European Journal of Immunology, vol. 41, no. 1, 2016, pp. 25-30. doi:10.5114/ceji.2016.58311.

Vancouver

Radomska-Leśniewska D, Skopińska-Różewska E, Demkow U, Jóźwiak J, Sobiecka M, Bałan B. A natural herbal remedy modulates angiogenic activity of bronchoalveolar lavage cells from sarcoidosis patients. Central European Journal of Immunology. 2016;41(1):25-30. doi:10.5114/ceji.2016.58311.

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Sarcoidosis is a systemic inflammatory disease with abnormally high angiogenic activity of inflammatory cells. Reumaherb preparation consisting of three herbs: Echinacea purpurea, Harpagophytum procumbens, and Filipendula ulmaria, and it exerts anti-inflammatory, antioxidant, and analgesic activity and stimulates regenerative and immunological processes.

The aim of this paper was to estimate the effect of Reumaherb on immunological angiogenesis induced by bronchoalveolar lavage (BAL) cells collected from six patients with sarcoidosis and grafted into Balb/c mice skin. After grafting, the animals were fed for three days with 0.6 or 1.2 mg of Reumaherb (calculated from recommended human daily dose) daily, suspended in 40 µl of water, or 40 µl of water alone (control group).

A significant reduction of newly formed blood vessels was obtained in four cases for 1.2 mg and in three cases for 0.6 mg daily dose of this remedy. Thus, we hypothesise that Reumaherb promotes anti-angiogenic activity and may potentially be used in diseases associated with excessive blood vessel formation.

keywords:

A natural herbal remedy modulates angiogenic activity of bronchoalveolar lavage cells from sarcoidosis patients

Dorota M. Radomska-Leśniewska , Ewa Skopińska-Różewska , Urszula Demkow , Jarosław Jóźwiak , Małgorzata Sobiecka , Barbara Joanna Bałan

sarcoidosis, bronchoalveolar lavage cells, BAL, herbal remedy, leukocyte-induced angiogenesis, LIA, murine skin

Dorota M. Radomska-Leśniewska

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Ewa Skopińska-Różewska

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Urszula Demkow

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Jarosław Jóźwiak

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Małgorzata Sobiecka

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Barbara Joanna Bałan