facebook
eISSN: 2084-9893
ISSN: 0033-2526
Dermatology Review/Przegląd Dermatologiczny
Current issue Archive Manuscripts accepted About the journal Special Issues Editorial board Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
4/2016
vol. 103
 
Share:
Share:
abstract:
Review paper

Application of antimalarial medications in the treatment of skin diseases

Katarzyna M. Chyl-Surdacka
,
Joanna Przepiórka-Kosińska
,
Agnieszka Gerkowicz
,
Dorota Krasowska
,
Grażyna Chodorowska

Przegl Dermatol 2016, 103, 316–322
Online publish date: 2016/09/01
View full text Get citation
 
PlumX metrics:
Antimalarial drugs used in medicine for over 300 years, nowadays, due to their anti-inflammatory, immunomodulatory and antiproliferative photoprotective properties, are used in the therapy of many dermatologic and rheumatologic disorders. The efficacy of these medications is proven in systemic lupus erythematosus, rheumatoid arthritis, porphyria cutanea tarda, lichen planus, ulcerative stomatitis, sarcoidosis, and even alopecia areata. Chloroquine and hydroxychloroquine belong to a group of well-tolerated drugs that occasionally cause adverse effects, which include gastrointestinal disorders, retinopathy, cardiomyopathy, neuromuscular disorders, skin hyperpigmentations, and hematological disorders. Nevertheless, these drugs continue to be frequently applied, including for systemic diseases of connective tissue during pregnancy. However, the treatment must be monitored – periodic ophthalmologic examinations during therapy with chloroquine must be performed, especially during prolonged treatment with high doses of these drugs. The article discusses the mechanism of action, pharmacokinetics, indications and adverse effects of these medications.
keywords:

systemic lupus erythematosus, adverse events, retinopathy, antimalarial drugs



Quick links
© 2024 Termedia Sp. z o.o.
Developed by Bentus.