eISSN: 1897-4309
ISSN: 1428-2526
Contemporary Oncology/Współczesna Onkologia
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SCImago Journal & Country Rank
2/2016
vol. 20
 
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abstract:
Original paper

Clinical outcomes and prognostic factors of adult’s Ewing sarcoma family of tumors: single center experience

Ummugul Uyeturk
,
Kaan Helvaci
,
Ayse Demirci
,
Ozlem Uysal Sonmez
,
Ibrahim Turker
,
Cigdem Usul Afsar
,
Burcin Budakoglu
,
Ulku Yalcintas Arslan
,
Omur Berna Oksuzoglu
,
Nurullah Zengin

Contemp Oncol (Pozn) 2016; 20 (2): 141-146
Online publish date: 2016/03/21
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Aim of the study was to investigate the demographics of Ewing sarcoma family of tumours (ESTF) patients, treatment alternatives, clinical outcomes, and prognostic factors for survival.

Material and methods: We retrospectively reviewed 39 patients with ESFT who were admitted to our institute between September 2008 and September 2012.

Results: The patients included 32 (82.1%) males and seven (17.9%) females of median age 24 (range, 18–66) years. Among the 27 patients with a primary osseous localization, 17 (43.5%) had a central axis localization. Fifteen patients (38.5%) had metastases at the time of diagnosis. Patients were followed up for a median period of 18 (range, 2–134) months. The median event-free survival (EFS) was 23 (range, 1–64) months, and the 1- and 4-year EFS were 60% and 48%, respectively. The median overall survival (OS) was 91 (range, 1–188) months, and the 1- and 4-year OS were 78% and 54%, respectively. Gender, age, primary tumor site, and local treatment modalities, either alone or in combination, did not have a significant effect on OS (p = 0.210, p = 0.617, p = 0.644, and p = 0.417, respectively). In contrast, osseous site of peripheral localization, limited stage, and metastasis to the bone significantly affected OS (p = 0.015, p < 0.001, and p = 0.042, respectively).

Discussion: ESFTs are aggressive tumors with a high rate of relapse and metastatic potential. Patients with peripheral bone involvement and limited stage had a good prognosis. Appropriate surgical resection, radiotherapy, and aggressive chemotherapy regimens are recommended.
keywords:

Ewing’s sarcoma family of tumors, adult, treatment

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