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eISSN: 2084-9893
ISSN: 0033-2526
Dermatology Review/Przegląd Dermatologiczny
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SCImago Journal & Country Rank
4/2016
vol. 103
 
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abstract:
Review paper

Infectious agents in the pathogenesis of rosacea

Dorota M. Mehrholz
,
Roman Nowicki
,
Wioletta M. Barańska-Rybak

Przegl Dermatol 2016, 103, 323–329
Online publish date: 2016/09/01
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Acne rosacea is a chronic inflammatory skin disease that affects the face. The symptoms depend on the stage of the disease. The first stage is characterized by erythema and telangiectasia. This is followed by a papulopustular phase and a phymatous type in the final stages. An ocular type of rosacea is described in the literature as well. In the etiopathogenesis of papulo-pustular and ocular types of rosacea, inflammatory response modulation caused by microorganisms living on the skin play a key role. Binding of bacterial ligands with epidermal receptors leads to induction of the inflammatory cascade. This leads to vasodilation and white blood cell chemotaxis, which causes a change in the microenvironment of the skin that assists in microorganism proliferation. Microorganisms such as Demodex folliculorum, Bacillus oleronius, Staphylococcus epidermidis, Chlamydia pneumoniae and Helicobacter pylori play a crucial role in the pathogenesis of rosacea.
keywords:

Helicobacter pylori, etiology, rosacea, Demodex folliculorum, Staphylococcus epidermidis



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