Archives of Medical Science
 
SCImago Journal & Country Rank
Search
1/2011
 
Share:
Share:
more
 
 
abstract:

Review paper
Is the metabolic syndrome caused by a high fructose, and relatively low fat, low cholesterol diet?

Stephanie Seneff, Glyn Wainwright, Luca Mascitelli

Arch Med Sci 2011; 7, 1: 8-20
DOI (digital object identifier): 10.5114/aoms.2011.20598
The metabolic syndrome (MetS) is manifested by a lipid triad which includes elevated serum triglycerides, small LDL particles, and low high-density lipoprotein (HDL) cholesterol, by central obesity (central adiposity), insulin resistance, glucose intolerance and elevated blood pressure, and it is associated with an increased risk of type 2 diabetes and coronary heart disease. We have developed a new hypothesis regarding MetS as a consequence of a high intake in carbohydrates and food with a high glycemic index, particularly fructose, and relatively low intake of cholesterol and saturated fat. We support our arguments through animal studies which have shown that exposure of the liver to increased quantities of fructose leads to rapid stimulation of lipogenesis and accumulation of triglycerides. The adipocytes store triglycerides in lipid droplets, leading to adipocyte hypertrophy. Adipocyte hypertrophy is associated with macrophage accumulation in adipose tissue. An important modulator of obesity-associated macrophage responses in white adipose tissue is the death of adipocytes. Excess exposure to fructose intake determines the liver to metabolize high doses of fructose, producing increased levels of fructose end products, like glyceraldehyde and dihydroxyacetone phosphate, that can converge with the glycolytic pathway. Fructose also leads to increased levels of advanced glycation end products. The macrophages exposed to advanced glycation end products become dysfunctional and, on entry into the artery wall, contribute to plaque formation and thrombosis.
keywords:

cholesterol, fructose, metabolic syndrome

Featured products
Books:

NOWOŚĆ!
Bates – kieszonkowy przewodnik po badaniu podmiotowym i przedmiotowym
Lynn S. Bickley

REDAKTORZY WYDANIA POLSKIEGO:
prof. dr hab. n. med. Zbigniew Gaciong
dr n. med. Piotr Jędrusik


Format: 108x180
Liczba stron: 432
Oprawa: miękka
 
Kompresjoterapia
pod redakcją Arkadiusza Jawienia
i Marii T. Szewczyk

format A5
liczba stron 152
oprawa miękka
 
Cała prawda o e-papierosach

Jean-François Etter, Gérard Mathern

Format: 125x197 mm
Liczba stron: 208
Oprawa: miękka
 
Internet:
Studenci Medycyny i Farmacji
Portal adresowanych do studentów uczelni medycznych w Polsce i za granicą.
Privacy policy Advertising policy Contact us
Stosujemy się do standardu HONcode dla wiarygodnej informacji zdrowotnej This site complies with the HONcode standard for trustworthy health information: verify here
Created by Bentus
PayU - płatności internetowe