eISSN: 1689-1716
ISSN: 0324-8267
Archiwum Medycyny Sądowej i Kryminologii/Archives of Forensic Medicine and Criminology
Current issue Archive Manuscripts accepted About the journal Supplements Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures
SCImago Journal & Country Rank
3/2016
vol. 66
 
Share:
Share:
abstract:
Review paper

Variation in gastric alcohol dehydrogenase and the risk of alcohol dependence

Paulina Całka
1, 2
,
Marzanna Ciesielka
1
,
Grzegorz Buszewicz
1
,
Grzegorz Teresiński
1

1.
Chair and Department of Forensic Medicine, Medical University in Lublin
2.
Postgraduate School of Molecular Medicine
Arch Med Sąd Kryminol 2016; 66 (3): 172-181
Online publish date: 2017/03/15
View full text Get citation
 
PlumX metrics:
Alcohol dependence is both a medical and socioeconomic problem. The disease is multifactorial, i.e. its development is attributable to gene-gene and gene-environment interactions. Multi-centre studies investigating the genetic background of alcoholism stress the role of genes encoding enzymes of the ethanol decomposition pathway in the human body, particularly alcohol dehydrogenase (ADH), in the development of alcohol dependence. Among five classes of alcohol dehydrogenases, class I and IV isoenzymes have been found to be associated with alcohol dependence. Class IV is of particular interest due to its occurrence in the upper gastrointestinal tract, mainly in the stomach. No activity of the enzyme has been demonstrated in the liver. Single nucleotide polymorphism (SNP) of the gene encoding ADH class IV (ADH7) affects its ethanol-oxidizing activity in the gastric lumen, thereby influencing the first-pass metabolism (FPM) of the substance. The findings published by various research centres have demonstrated that specific SNP changes in the ADH7 gene are of different significance for the risk of alcohol dependence according to the population studied.
keywords:

ADH7, alcoholism, first-pass metabolism

Quick links
© 2024 Termedia Sp. z o.o.
Developed by Bentus.