TY - JOUR JO - Contemporary Oncology/Współczesna Onkologia SN - 1428-2526 VL - 14 IS - 5 PY - 2010 ID - Cybulska-Stopa2010 TI - Treatment results in patients with lymphoblastic lymphoma ­treated at the Centre of Oncology, Krakow Division AB - Between 1980 and 2000, 30 patients with lymphoblastic lymphoma were treated at the Medical Oncology Clinic of the Centre of Oncology (Krakow Division). At first the APO and Coleman’s treatment protocols were used. In 1993, in order to improve treatment results, a modification of Coleman’s regimen was introduced, i.e. the dose of doxo­rubicin was intensified. In the original Coleman’s regimen doxorubicin is ad­mini­stered at the dose of 50 mg/m 2 on days 1, 22 and 57 of the induction phase. According to our modification doxorubicin was administered on days 1, 15, 29, 43 and 57 of the induction phase. Complete remission of malignancy was achieved in 20 patients (67%). Partial remission was achieved in 3 patients (10%). In total, objective remission (CR + PR) was achieved in 23, i.e. 77% of treated patients, 37% survived 2 years and 33% survived 5 years. The most common adverse events observed during therapy were haematological complications: anaemia, gra­nulocytopenia and thrombocytopenia. They were the cause of one treatment-related death (neutropenic fever). Hyperglycaemia was observed due to use of high doses of steroids in the chemotherapy regimens under consi­deration. Increased intensity of anthracycline administration in our modification of Coleman’s regimen was not associated with increased frequency of cardiological complications; however, the total dose did not exceed the acceptable cumulative dose of this medi­cation. AU - Cybulska-Stopa, Bożena AU - Rolski, Janusz AU - Ziobro, Marek AU - Hetnał, Marcin SP - 310 EP - 315 DA - 2010 DO - 10.5114/wo.2010.17294 UR - http://dx.doi.org/10.5114/wo.2010.17294 ER -