en POLSKI
eISSN: 2083-8441
ISSN: 2081-237X
Pediatric Endocrinology Diabetes and Metabolism
Current issue Archive Manuscripts accepted About the journal Supplements Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
1/2017
vol. 23
 
Share:
Share:
abstract:
Review paper

Y chromosome in Turner syndrome

Aleksandra Rojek
,
Karolina Kwasiuk
,
Monika Obara-Moszyńska
,
Zofia Kolesińska
,
Marek Niedziela

Pediatr Endocrinol Diabetes Metab 2017;23,1:37-41
Online publish date: 2017/10/11
View full text Get citation
 
Turner syndrome (TS) is an inherited genetic disorder caused by numerical and/or structural chromosome X aberrations occurring  at a frequency of 1:1200–1:2500 live-born girls. The most common karyotype is X chromosome monosomy (45,X) (approximately 50–60% of cases). Approximately 5–6% of patients may have abnormal Y chromosome or mosaicism characterized by the coexistence of 45,X cell line with cell line in which all or part of chromosome Y is present. In patients with TS who have all or fragmented genetic material from chromosome Y there is a substantial risk of cancerous lesions in these dysgenetic gonads. This paper stands for the review of the current knowledge on the genetic material of the Y chromosome in TS, especially in view of the risk of developing malignancies such as gonadoblastoma and dysgerminoma.
keywords:

Turner syndrome, mosaicism, Y chromosome


Quick links
© 2024 Termedia Sp. z o.o.
Developed by Bentus.