Response to low dose indomethacin in two children with nephrogenic diabetes insipidus

Devi Dayal; Savita Verma Attri; Anil Kumar Bhalla; Rakesh Kumar

eISSN: 2083-8441
ISSN: 2081-237X

Pediatric Endocrinology Diabetes and Metabolism

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abstract:

Case report

Response to low dose indomethacin in two children with nephrogenic diabetes insipidus

Devi Dayal

,

Savita Verma Attri

,

Anil Kumar Bhalla

,

Rakesh Kumar

Pediatr Endocrinol Diabetes Metab 2014;22,4:178-181

Online publish date: 2015/08/31

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Two children with nephrogenic diabetes insipidus (NDI) were treated with oral indomethacin (0.75-1.2 mg/kg/day) three times a day for a mean duration of 3 yrs. Remission occurred in both patients in terms of achieving a normal fluid balance and body growth and the drug was withdrawn in one patient after 2 yrs. The treatment was well tolerated and no side effects were noted. The mean duration of follow-up was 6.5 yrs. These long-term observations of a favourable response to low dose indomethacin in 2 children with NDI need to be tested on larger number of patients.

keywords:

Response to low dose indomethacin in two children with nephrogenic diabetes insipidus

Devi Dayal , Savita Verma Attri , Anil Kumar Bhalla , Rakesh Kumar

nephrogenic diabetes insipidus, cyclooxygenase inhibitors, indomethacin, children

Devi Dayal

,

Savita Verma Attri

,

Anil Kumar Bhalla

,

Rakesh Kumar