en POLSKI
eISSN: 2084-9834
ISSN: 0034-6233
Reumatologia/Rheumatology
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SCImago Journal & Country Rank
 
1/2021
vol. 59
 
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abstract:
Case-based review

A fine line between macrophage activation syndrome and multisystem inflammatory syndrome in children – literature review based on two case reports

Agnieszka Poniecka
1
,
Elżbieta Smolewska
1, 2

1.
Department of Paediatric Cardiology and Rheumatology, Medical University of Lodz, Poland
2.
Pediatric Center Maria Konopnicka, Central Clinical Hospital of the Medical University of Lodz, Poland
Reumatologia 2021; 59, 1: 47–57
Online publish date: 2021/02/28
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Multisystem inflammatory syndrome in children is a newly described condition temporarily associated with severe acute respiratory syndrome coronavirus 2. The primary observations indicated coronavirus disease 2019 infection in children to be mild. However, recent reports have revealed a correlation between multisystem inflammatory symptoms and coronavirus infection. The manifestation of the disease is similar to Kawasaki disease, toxic shock syndrome and macrophage acti­vation syndrome. Treatment includes intravenous corticosteroids, immunoglobulin and biological therapy (anakinra, tocilizumab, infliximab).

In this article we compare world reports of multisystem inflammatory syndrome in children to case reports of two patients who were hospitalized recently at the Department of Paediatric Cardio­logy and Rheumatology. In the course of diagnostics they presented numerous symptoms which required differentiation from multisystem inflammatory syndrome in children.
keywords:

paediatric multisystem inflammatory syndrome, SARS-CoV-2 infection, secondary haemophagocytic lymphohistiocytosis, macrophage activation syndrome









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