Polish Journal of Pathology
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ISSN: 1233-9687
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3/2025
vol. 76
 
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Original paper

A retrospective analysis of secondary malignancy development in nevus sebaceus

Fatma Seher Pehlivan
1
,
Ömer Atmış
1
,
Hanife Seda Mavili
1
,
Peyker Temiz
1

  1. Department of Pathology, Faculty of Medicine, Manisa Celal Bayar University, Manisa, Turkey
Pol J Pathol 2025; 76 (3): 233-238
DOI: https://doi.org/10.5114/pjp.2025.157906
Online publish date: 2025/12/19
Article file
- A retrospective analysis.pdf  [5.89 MB]
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2. Baigrie D, Troxell T, Cook C. Nevus sebaceus. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
3. Lei T, Lu Y, Feng Y, Ni Y. Case report: basal cell carcinoma arising within the nevus sebaceous: report of 4 cases and literature review. Front Oncol 2025; 14: 1478747.
4. Calonje JE, Brenn T, Lazar AJ, Billings SD. mckee’s pathology of the skin. 5th ed. Medipage, Warszawa 2019.
5. Kamyab-Hesari K, Seirafi H, Jahan S, Aghazadeh N, Hejazi P, Azizpour A, et al. Sebaceous nevus: a clinicopathological study of 168 cases and review of the literature. Int J Dermatol 2016; 55: 193-200.
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8. Aslam A, Salam A, Griffiths CE, McGrath JA. Sebaceous nevus: a mosaic RASopathy. Clin Exp Dermatol 2014; 39: 1-6.
9. Groesser L, Herschberger E, Ruetten A, Ruivenkamp C, Lopriore E, Zutt M, et al. Postzygotic HRAS and KRAS mutations cause nevus sebaceous and Schimmelpenning syndrome. Nat Genet 2012; 44: 783-787.
10. Kim YS, Park GS, Chung YJ, Lee JH. Whole-exome sequencing of secondary tumors arising from nevus sebaceous revealed additional genomic alterations besides RAS mutations. J Dermatol 2023; 50: 1072-1075.
11. Ye Q, Wu Q, Jia M, Li FZ, Fang S. Secondary tumors arising from nevus sebaceus: a multicenter collaborative study and literature review. Dermatology 2023; 239: 140-147.
12. Pang S, Cevik J, Sreedharan S, Wilks DJ. Rate of benign and malignant secondary tumors associated with nevus sebaceous: a systematic review and meta-analysis. Ann Plast Surg 2024; 92: 711-719.
13. Silva Neto MP, de Assis BR, Andrade GR. Sebaceous nevus of Jadassohn: review and clinical-surgical approach. An Bras Dermatol 2022; 97: 628-636.
14. Kong SH, Han SH, Kim JH, Oh YW, Park HJ, Suh HS, et al. Optimal timing for surgical excision of sebaceous nevus on the scalp: a single-center experience. Dermatol Surg 2020; 46: 20-25.
15. Hashem R, Tynngård N, Lundmark K, Falk L. Microcystic adnexal carcinoma originating in a sebaceous nevus: a case report of a 16-year-old boy. Acta Derm Venereol 2019; 99: 1182-1183.
16. Pepi C, de Palma L, Trivisano M, Pietrafusa N, Lepri FR, Diociaiuti A, et al. The role of KRAS mutations in cortical malformation and epilepsy surgery: a novel report of nevus sebaceous syndrome and review of the literature. Brain Sci 2021; 11: 793.
17. Happle R. Nevus sebaceus is a mosaic RASopathy. J Invest Dermatol 2013; 133: 597-600.
18. Pan C, Zhou X, Hong A, Fang F, Wang Y. Identification of KRAS mutation in a patient with linear nevus sebaceous syndrome: a case report. BMC Med Genomics 2020; 13: 188.
19. Fernandes DA, Sang K, Sperling L. Sebaceous nevus with novel HRAS sequence variant mutation misdiagnosed as alopecia areata. Cutis 2023; 111: E30-E32.
Copyright: © 2025 Polish Association of Pathologists and the Polish Branch of the International Academy of Pathology This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (http://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
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