A review of the mechanisms and biomarkers of allergen immunotherapy

Mateusz Wilk; Jakub Ptak; Bartosz Tomczyk; Adrianna Kruczkowska; Andrzej Kanturski; Krzysztof Gomułka

doi:10.5114/ms.2021.112388

eISSN: 2300-6722
ISSN: 1899-1874

Medical Studies/Studia Medyczne

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4/2021
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abstract:

Review article

A review of the mechanisms and biomarkers of allergen immunotherapy

Mateusz Wilk

¹

,

Jakub Ptak

¹

,

Bartosz Tomczyk

¹

,

Adrianna Kruczkowska

¹

,

Andrzej Kanturski

¹

,

Krzysztof Gomułka

²

Student Research Group of Adult Allergology, Wroclaw Medical University, Wroclaw, Poland Head of the Group: Dr Krzysztof Gomułka

Department of Internal Medicine, Pneumology and Allergology, Wroclaw Medical University, Wroclaw, Poland Head of the Department: Wojciech Barg MD, DSc

Medical Studies/Studia Medyczne 2021; 37 (4): 322–330

DOI: https://doi.org/10.5114/ms.2021.112388

Online publish date: 2021/12/31

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Allergen immunotherapy has been shown to be successful in numerous clinical trials, even leading to complete relief of allergic symptoms. However, the molecular mechanisms behind these outcomes remain unclear, substantially hindering introduction of more efficient and safer protocols. The current gold standard of assessing the effects of allergen immunotherapy is a challenge test, which might be both unpleasant and dangerous for patients. Better understanding of the molecular background of allergen immunotherapy would allow us to substitute challenge tests with biomarkers. These might also be used to predict a patient’s response to the treatment. Here, we review current knowledge regarding immune responses to allergen immunotherapy and its potential biomarkers.

keywords:

A review of the mechanisms and biomarkers of allergen immunotherapy

Mateusz Wilk 1 , Jakub Ptak 1 , Bartosz Tomczyk 1 , Adrianna Kruczkowska 1 , Andrzej Kanturski 1 , Krzysztof Gomułka 2

immunotherapy, allergy, desensitization

Mateusz Wilk

¹

,

Jakub Ptak

¹

,

Bartosz Tomczyk

¹

,

Adrianna Kruczkowska

¹

,

Andrzej Kanturski

¹

,

Krzysztof Gomułka

²