ISSN: 2451-0637
Archives of Medical Science - Civilization Diseases
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1/2021
vol. 6
 
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abstract:
Experimental research

A study to reveal the effectiveness of taxifolin in sunitinib-induced oxidative muscle damage in rats

Hasan Yaşar
1
,
Ceyda Tanoglu
1
,
Mine Gulapoglu
2
,
Halis Suleyman
3
,
Gülce Naz Yazıcı
4
,
Yusuf Kemal Arslan
5

1.
Department of Neurology, Medicine Faculty, Erzincan Binali Yıldırım University, Erzincan, Turkey
2.
Department of Biochemistry, Erzurum Atatürk University, Turkey
3.
Department of Pharmacology, Erzincan Binali Yıldırım University, Erzincan, Turkey
4.
Department of Histology, Erzincan Binali Yıldırım University, Erzincan, Turkey
5.
Department of Biostatistics, Erzincan Binali Yıldırım University, Erzincan, Turkey
Arch Med Sci Civil Dis 2021; 6: e103–e108
Online publish date: 2021/09/20
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Introduction
The aim of this study is to examine the oxidative damage caused by sunitinib on skeletal muscle and whether taxifolin is effective against that oxidative damage.

Material and methods
Thirty albino Wistar male rats were used in the experiment. The rats were divided into 3 equal-sized groups: a sunitinib-only administered group (SUN), a sunitinib + taxifolin administered group (SUT), and a control group (CG) without treatment. Taxifolin and sunitinib were administered by oral gavage at a dose of 50 mg/kg for taxifolin and a dose of 25 mg/kg for sunitinib. Striated hind limb muscle tissue of rats was removed; malondialdehyde (MDA), reduced glutathione (GSH), and superoxide dismutase (SOD) levels were measured in muscle tissue; muscle tissue was examined histopathologically; creatine kinase (CK) levels were determined in the blood samples of rats; and the results were compared between the groups.

Results
In the SUN group, MDA and CK values were statistically significantly higher than in the SUT and CG groups, but SOD and GSH values were statistically significantly lower. The SUT and CG groups were similar when compared. Histopathologically, congested blood vessels, oedema, degeneration, inflammation, and rupture of muscle fibres in muscle tissue were detected in the SUN group. However, in the SUT group it was observed that blood vessels were normal, there were no degenerative findings, and inflammation was resolved.

Conclusions
Sunitinib causes oxidative damage to skeletal muscle tissue. Taxifolin prevents the toxic effect of sunitinib on skeletal muscle due to its antioxidant effects.

keywords:

skeletal muscle, sunitinib, oxidative damage, taxifolin

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