eISSN: 2299-0046
ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
Current issue Archive Manuscripts accepted About the journal Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors
SCImago Journal & Country Rank
5/2022
vol. 39
 
Share:
Share:
more
 
 
abstract:
Original paper

Analysis of selected genetic variants in psoriasis susceptibility and response to treatment

Damian Malinowski
1
,
Monika Białecka
1
,
Piotr Bojko
2
,
Adriana Kiszkielis
3
,
Marek Droździk
4
,
Mateusz Kurzawski
4

1.
Department of Pharmacokinetics and Therapeutic Drug Monitoring, Pomeranian Medical University, Szczecin, Poland
2.
Aesthetic Dermatology Centre “Hippocrates”, Szczecin, Poland
3.
The 2nd Department of Ophthalmology, Pomeranian Medical University, Szczecin, Poland
4.
Department of Experimental and Clinical Pharmacology, Pomeranian Medical University, Szczecin, Poland
Adv Dermatol Allergol 2022; XXXIX (5): 934-939
Online publish date: 2022/11/09
View full text
Get citation
ENW
EndNote
BIB
JabRef, Mendeley
RIS
Papers, Reference Manager, RefWorks, Zotero
AMA
APA
Chicago
Harvard
MLA
Vancouver
 
Introduction
Aetiology of psoriasis is complex with risk factors involving both environmental triggers and genetic background. Although the best characterized genetic risk factor for psoriasis is HLA-C*06 allele, a number of other variants were associated with the disease.

Aim
In the current paper we have conducted a confirmation study for SNPs located in 9 gene regions in a case-control analysis of 507 psoriatic patients and 396 controls from the Polish population.

Material and methods
Subsequently the impact of genetic variants on response to topical and NB-UVB therapy (reduction in the Psoriasis Area and Severity Index) was analysed.

Results
Significant differences in genotype and/or allelic frequency were observed for the following SNPs: rs33980500 (TRAF3IP2), rs582757 (TNFAIP3I), rs12188300 (IL12B), rs28998802 (NOS2), and rs2233278 (TNIP1). None of the genetic factors was associated with treatment outcome.

Conclusions
Although the genetic variants have an impact on the disease risk, they are unlikely to be useful in personalization of topical therapy.

keywords:

psoriasis, SNP, NB-UVB

Quick links
© 2022 Termedia Sp. z o.o. All rights reserved.
Developed by Bentus.