Abstract
Anti-inflammatory activity of Anthemis tricolor Boiss
- Department of Dermatology and Venerology, Faculty of Medicine, Kirikkale University, Kirikkale, Turkey
- Department of Pharmacognosy, Faculty of Pharmacy, Ege University, İzmir, Turkey
Introduction
Traditionally, Anthemis genus has been used for the treatment of gastrointestinal disorders, haemorrhoid and stomach ache in Europe. There are several in-vitro and in-vivo studies that showed the pharmacological properties of Anthemis species such as antibacterial, anti-inflammatory, antiedemic and hepatoprotective properties.
Aim
Our study referred to the model of inflammation formed in rats; we aimed to evaluate anti-inflammatory properties of A. tricolor extracts.
Material and methods
Five different extracts of A. tricolor were tested against the negative control and 2 different topical corticosteroids (betamethasone and hydrocortisone); n-hexane and sesquiterpene extracts of A. tricolor Bois showed significantly reduced erythema compared to the negative control.
Results
Only n-hexane and sesquiterpene extracts of A. tricolor have the anti-inflammatory effect.
Conclusions
This is the first report on anti-inflammatory activity of A. tricolor and we showed an anti-inflammatory effect of n-hexane and sesquiterpene extract of A. tricolor with UV erythema test as a result, hence A. tricolor extracts can be used for the treatment of inflammatory skin diseases due to anti-inflammatory activity.
Keywords
Anthemis tricolor, anti-inflammatory, n-hexane, sesquiterpene, minimal erythema dose
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