Anti-lamin A/C antibodies in patients with Behçet’s disease

Peng Chen; Hai Yan; Wen Zhang; Chunhe Yang; Hongwu Du

doi:10.5114/ceji.2018.80058

eISSN: 1644-4124
ISSN: 1426-3912

Central European Journal of Immunology

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3/2018
vol. 43

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abstract:

Short communication

Anti-lamin A/C antibodies in patients with Behçet’s disease

Peng Chen

,

Hai Yan

,

Wen Zhang

,

Chunhe Yang

,

Hongwu Du

Centr Eur J Immunol 2018; 43 (3): 358-361

DOI: https://doi.org/10.5114/ceji.2018.80058

Online publish date: 2018/10/30

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Lamin A/C has been identified as a target antigen of anti-endothelial cell antibodies in vasculitis. Behçet’s disease (BD) is a chronic vasculitis with unclear pathogenesis. Self-antibodies have been found to play an important role in the pathological process of BD. The aim of this study was to verify whether lamin A/C is an autoantigen of BD. First, the human lamin A/C protein was cloned and purified and verified by Western blotting. Next, a homemade ELISA kit was used to test the presence of anti-lamin A/C antibodies in BD patients. This is the first time it has been certified that lamin A/C is an autoantigen of BD. The reactivity of serum IgG against recombinant human lamin A/C was detected in 7 of 31 BD patients (23%) and 3 of 32 healthy controls (HC) (9%).

keywords:

Anti-lamin A/C antibodies in patients with Behçet’s disease

Peng Chen , Hai Yan , Wen Zhang , Chunhe Yang , Hongwu Du

Behçet’s disease, autoantigen, lamin A/C

Peng Chen

,

Hai Yan

,

Wen Zhang

,

Chunhe Yang

,

Hongwu Du