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eISSN: 2084-9834
ISSN: 0034-6233
Reumatologia/Rheumatology
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4/2018
vol. 56
 
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abstract:
Review paper

Antinuclear antibodies in healthy people and non-rheumatic diseases – diagnostic and clinical implications

Bogna Grygiel-Górniak
,
Natalia Rogacka
,
Mariusz Puszczewicz

Reumatologia 2018; 56, 243–248
Online publish date: 2018/08/31
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The presence of antinuclear antibodies (ANA) is mainly associated with connective tissue diseases (CTD). In addition, their presence is found in healthy people. These antibodies are more common in women and the elderly. Some drugs and xenobiotics are also important for the development of autoimmunity and ANA synthesis. Moreover, the deficiency of vitamin D in the body of patients correlates with occurrence of these antibodies. Unlike the healthy group, a positive ANA count was observed in patients with atopic dermatitis (AD) and in people with immune disorders. Antinuclear antibodies in low counts are also found in the course of chronic bacterial or viral infection and in patients with hematological malignancies. Also the possibility of false positive results, which may be caused by the choice of method used to determine antibodies, should be borne in mind. Taking into account all these factors, it is concluded that the ANA result itself has no diagnostic value.
keywords:

antinuclear antibodies, autoimmune diseases, methods of detection







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