eISSN: 1896-9151
ISSN: 1734-1922
Archives of Medical Science
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SCImago Journal & Country Rank
5/2019
vol. 15
 
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abstract:
Experimental research

Antisense of survivin inhibits cervical cancer growth in mice

Hui Xu
,
Tingting Liang
,
Yongxia Yang
,
Yanlei Dong
,
Lin Zhu

Arch Med Sci 2019; 15 (5): 1345–1351
Online publish date: 2019/09/06
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Introduction
It is proposed that survivin plays a critical role in the pathogenesis of cancer. Immune regulatory cells are associated with the growth of cancer in the body. Antisenses for the key molecules can suppress tumor growth. This study tests the hypothesis that the antisense of survivin can inhibit cervical cancer.

Results
The results showed that human cervical cancer cells expressed high levels of survivin. The levels of survivin in cervical cancer positively correlated with the frequency of interleukin (IL)-10-producing B cells (B10 cells) in the cancer tissue. Survivin increased the expression of IL-10 in B cells. Exposure to survivin antisense efficiently decreased IL-10 expression in B cells. Administration of antisense of survivin inhibited cervical cancer growth and reduced the frequency of B10 cells in tumor-bearing mice.

Conclusions
The results suggest that the survivin antisense has the potential to be used in the treatment of cervical cancer.

keywords:

cervical cancer, surviving, interleukin-10, B lymphocyte

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