eISSN: 2084-9869
ISSN: 1233-9687
Polish Journal of Pathology
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SCImago Journal & Country Rank
1/2014
vol. 65
 
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abstract:

Appearance of estrogen positive bilateral breast carcinoma with HER2 gene amplification in a patient with aplastic anemia

Milica Čolović
,
Milena Todorović
,
Natasa Čolović
,
Tatjana Terzic
,
Katarina Karadzic
,
Vladimir Jurišić

Pol J Pathol 2014; 65 (1): 66-69
Online publish date: 2014/05/13
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Immunosuppressive therapy is one of the standard therapy protocols for aplastic anemia (AA). However, immunosuppressive therapy and androgenic steroids can promote development of solid tumors such as squamous carcinoma, head and neck tumors, adenocarcinoma of the stomach, hepatocarcinoma and breast carcinoma in long surviving patients with aplastic anemia. We present here a rare case of a 56-year-old woman in whom bilateral adenocarcinoma of the breast developed 11 years after the start of immunosuppressive and androgenic steroid therapy for aplastic anemia. Histological examination showed invasive ductal carcinoma with intense nuclear staining for estrogen receptors. Her2 immunohistochemistry was positive for 80% of stained cells, and chromogenic in situ hybridization showed a high level of HER2 gene amplification. This case indicated that a new therapy option is needed for estimation and evaluation to avoid the consequence of cancer occurrence.
keywords:

aplastic anemia, immunosuppressive therapy, breast cancer, histology, immunohistochemistry, estrogen receptors, Her2, survival, cancer, chromogenic in situ hybridization (CISH)

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