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Clinical research

Assessment of anxiety and health-related quality of life in patients with lower extremity peripheral arterial occlusive disease

Yalcin Guzelhan
1
,
Didem Melis Oztas
2
,
Cenk Conkbayir
3
,
Orhan Rodoplu
4
,
Ibrahim Erdinc
5
,
Cagla Canbay
6
,
Murat Ugurlucan
6
,
Ufuk Alpagut
6
,
Nilgun Bozbuga
6

1.
Department of Psychiatry, Istanbul Education and Research Hospital, Istanbul, Turkey
2.
Cardiovascular Surgery Clinic, Bagcilar Training and Research Hospital, Istanbul, Turkey
3.
Department of Cardiology, Near East University, Nicosia, Cyprus
4.
Cardiovascular Surgery Clinic, Kadikoy Medicana Hospital, Istanbul, Turkey
5.
Cardiovascular Surgery Clinic, Izmir Bozyaka Education and Research Hospital, Izmir, Turkey
6.
Department of Cardiovascular Surgery, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey
Arch Med Sci Atheroscler Dis 2020; 5: e212–e218
Online publish date: 2020/07/27
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Introduction

Peripheral arterial disease (PAD) is one of the important causes of morbidity and mortality. Atherosclerosis is the main etiological factor of peripheral artery disease [1]. The traditional objectives of intervention in patients with PAD have been symptomatic relief and limb salvage. In recent years, the goal of surgical intervention in patients with PAD has evolved to improve functional status. Patients are selected for intervention or surgery according to life-style limitation severity, ulceration or risk of limb loss. Although limb salvage and improving functional status are the stated goals of intervention or surgery in PAD by providing distal perfusion, the importance of these therapeutic goals lies in their potential for improving health-related quality of life (HRQoL) [24].

Physical factors, patient’s health-related quality of life (HRQoL), such as physical health, psychological condition, and social relations, also influence the postoperative outcome and thereby long term survival after intervention or surgery [5]. Direct measurements of HRQoL in patients with PAD have been relatively uncommon.

The World Health Organization (WHO) describes quality of life as “an individual’s perception of their position in life in the context of the culture and value system in which they live and in relation to their goals, expectations, and standards and concerns” [6]. Health-related quality of life includes individual’s usual or expected physical, emotional and social states that are affected by the medical situation. According to the WHO’s disease-specific quality of life group, any generic health-related quality of life instrument should contain physical, psychologic, social, functional, and well-being fields [710]. In peripheral arterial occlusive disease pathology, disease-specific quality of life measures aim to show a patient’s condition of a specific illness or treatment [11, 12].

The aim of the present study was to investigate the influence of psychological factors on major adverse cardiac event and to evaluate the hypotheses that symptoms of anxiety are associated with adverse clinical outcomes and quality of life in patients with chronic occlusive vascular disease requiring vascular intervention or surgery.

Material and methods

Three hundred and thirty-five patients who were intervened for peripheral arterial occlusive disease were enrolled in this study. The study was performed according to the principles of the Declaration of Helsinki. Demographic data on age, gender and education level (number of school years) were recorded. At enrollment, participants reported their smoking history (grouped as never, former, < 20 cigarettes per day, and ≥ 20 per day) (Table I).

Table I

Patients’ characteristics

ParameterNPercentage
Sex:
 Male28986.3
 Female4613.7
Age:
 Mean [years]62.6 ±10
 40–5016
 51–6025
 61–7034
 71–8021
 ≥ 811.5
Education level:
 Mean [years]6.95
 Secondary school and lower79.1
 High school12.4
 University and higher3.5
Smoking history (cigarettes per day):
 Never82
 Former smoking history6118.1
 Current smoking history:26679.4
  < 209034
  ≥ 2017666

Patient-related factors and comorbidities (diabetes mellitus, hypertension, hypercholesterolemia, obesity, ischemic heart disease, cerebrovascular disease, chronic renal failure, chronic obstructive pulmonary disease), clinical symptoms (claudication, atypical leg pain, ischemic leg pain, ulceration), angiographic findings (aorto-iliac disease, femoro-popliteal disease, distal artery disease) were recorded (Table II). Almost half of the series, 164 patients, have undergone previous lower extremity vascular surgery and 19 of them required contralateral amputation previously.

Table II

Risk factors, clinical and angiographic features

ParameterNPercentage
Comorbidities:
 Diabetes mellitus11736.1
 Hypertension23478.8
 Hypercholesterolemia27283.3
 Obesity8324.7
 Ischemic heart disease17050.9
 Cerebrovascular accident8324.8
 End-stage renal disease144.2
 Chronic obstructive pulmonary disease14041.8
 Previous lower extremity vascular surgery16449.1
 Previous contralateral vascular surgery amputation195.7
Symptoms:
 Claudication11735
 Atypical leg pain16549
 Ischemic leg pain5316
 Ulceration8024
Angiographic findings:
 Aorto-iliac disease7120
 CFA occlusion16148
 PopA occlusion5416
 ATA-PTA disease5416

[i] CFA – common femoral artery, PopA – popliteal artery, ATA – anterior tibial artery, PTA – posterior tibial artery.

One hundred and eighty-seven patients who had undergone percutaneous transluminal angioplasty and 148 patients who had one or more surgical revascularizations enrolled in the study.

At baseline 335 patients filled out the 36-item Medical Outcomes Short-Form Health Survey (SF-36) self-administered questionnaire [13] and the Spielberger State-Trait Anxiety Inventory (STAI) [14], 304 patients (90.7% of the series) at 6-month follow-up. A range of psychosocial, clinical and operative factors were collected as potential determinants of outcome.

Definition of Health-Related Quality of Life

The 36-item Medical Outcomes Short-Form Health Survey (SF-36) includes 36 questions in eight domains: general health condition (past and present health), physical capacity (based on performance of daily living), pain ( including intensity, frequency, duration and limitations in normal activities because of pain), mental status (emotional, cognitive, and intellectual conditions), physical life (usual activities according to age and social status), emotional life (feelings at work or daily activities), vitality (energy, fatigue, and tiredness), and social relationships. A score from zero to 100 is computed for the 8 scales. The SF-36 can provide 2 summary measures as the physical element score and mental component score [15]. It has been beneficial in evaluating well-known and unique populations, comparing the relative burden of diseases, differentiating the health advantages produced by means of an extensive variety of different treatments, and screening individual patients [15].

Measurement of anxiety

The two Spielberger State-Trait Anxiety Inventory sub-scores, the state (STAI-S) and the trait (STAI-T), have a high relation in people with or without generalized anxiety disorder. It contains “I feel nervous” and “I feel worried” statements. These items are scored on a 4-point scale of how they define the patient’s current or typical status from “not at all” to “very much so.” STAI scores range from 20 to 80. Higher scores reveal more severe symptoms, greater anxiety. The two STAI sub-scores have high association in people with or without anxiety. We accepted STAI scores less than 40 to indicate that there are minimal symptoms or there are no symptoms and higher than 40 to indicate that there are moderate or severe symptoms [16].

Statistical analysis

Statistical analysis was performed using the statistical software SPSS 20.0 for Windows (SPSS Inc., Chicago, IL). Data are expressed as mean values ±standard deviation for continuous variables and as numbers with percentage for categorical variables. The discrete variables were compared using the χ2 test and continuous variables were compared using a two-tailed t test. Differences obtained from the pre- and postoperative assessments were compared by Wilcoxon matched-pairs rank-sum test. Univariate analysis and logistic regression analysis were performed to identify the potential risk factors associated with quality of life and anxiety. A p-value of 0.05 or less was considered to be significant.

Results

There was no mortality and no significant morbidity after vascular interventions in the series. All of the 335 patients completed a short-form health survey (SF-36) and psychological self-reported questionnaires (STAI-S and STAI-T tests) and 304 of the series (90.7%) did so after a 6-month follow-up.

Significant improvement was found in two out of eight health domains – social functioning (p < 0.03) and general health perception (p < 0.04) – at 6-month follow-up. The two STAI sub-scores, the State Anxiety Inventory (STAI-S) and the Trait Anxiety Inventory (STAI-T) were found high (≥ 40) both preoperatively and 6 months postoperatively. Postoperatively there was no significant decrease of the levels of anxiety.

The patients’ repeated analysis of SF-36 and STAI Scores at baseline and 6-month follow-up are summarized in Table III.

Table III

Repeated-measures analysis of SF-36 score at baseline (n = 335) and 6-month follow-up (n = 304)

SF-36Baseline6-month follow-upP-value
Physical functioning51.7 (21.1)57.6 (25.4)0.08
Role limitation, physical health23.5 (34.6)30.6 (44.9)0.06
Bodily pain53.2 (24.2)56.8 (26.5)0.07
Social functioning52.6 (18.4)60.4 (21.1)0.03
General health44.4 (19.2)51.4 (16.4)0.08
Role limitation, emotional66.5 (25.4)70.6 (23.2)0.2
Vitality, energy, or fatigue56.8 (46.5)68.4 (40.2)0.07
General health perception60.5 (27.6)75.1 (21.1)0.04
Physical component35.6 (13.3)37.5 (13.2)0.2
Mental component39.2 (23.6)43.0 (24.5)0.4
STAI:
 STAI-S47 ±10.144 ±8.5NS
 STAI-T45 ±9.244 ±6.5NS

[i] SF-36 – Short-Form Health Survey, STAI – State-Trait Anxiety Inventory, STAI-S – State-Trait Anxiety Inventory “state” (current), STAI-T – State-Trait Anxiety Inventory “trait” (chronic).

Discussion

Health-related quality of life is one of the primary goals of treatment in patients with peripheral arterial disease; however, HRQoL is rarely measured directly. Recently HRQoL has been increasingly considered an important patient-oriented outcome measurement of cardiovascular interventions [1719].

The advances in perioperative anesthesia and intensive care have provided a significant decrease in mortality in perioperative or postoperative course. Considering that mortality has become relatively low after vascular surgery, development in health condition, modifications in functioning condition and feeling of well-being have come to be important indicators of the end result of peripheral vascular surgery [2, 4]. Recovery from peripheral arterial disease is not totally determined by means of physical attributes and medical remedies but social and mental factors can also influence the long-term healing [3, 19]. Despite good results of operations, morbidity-free and mortality-free courses, those parameters alone do not give sufficient data on a patient’s functional, emotional, and mental well-being [20]. Health-related quality of life can affect postoperative life for several reasons: complications of surgical therapy, recurrence or occurrence of non-vascular diseases, neurological and psychological complications, etc. Therefore, postoperative high quality of existence after these operations has become a crucial measure of the effectiveness of the vascular surgical procedure [21].

Health-related quality of life (HRQoL) contains an individual’s physical, emotional, and psychologic health, social and functional condition. However, a reliable, valid, responsive, sensitive standardized method that covers all health domains is necessary [22].

Questionnaires are the most often used technique of measuring quality of life. The 36-item Medical Outcomes Short-Form Health Survey self-administered questionnaire (SF-36) (Medical Outcomes Trust, Boston, MA) is a multipurpose, short-form health survey with only 36 questions [15]. The SF-36 Health Survey is one of the most useful standardized questionnaires provided to examine the functional status and well-being of patients and related to activities of daily life [13].

The Spielberger State-Trait Anxiety Inventory is one of the first tests that evaluates state and trait anxiety symptoms at the same time. The State-Trait Anxiety Inventory (STAI) consists of two 20-item scales that measure “state” (current) and “trait” anxiety (general) (STAI-S / STAI-T) [16]. The STAI tests diagnose the level of anxiety and distinguishes it from depressive syndromes [23].

The most commonly used questionnaires in cardiovascular diseases are the World Health Organization Quality Of Life Assessment Instrument (WHOQOL) (7), the Nottingham Health Profile (NHP) [24], the Euro-Quality of Life Questionnaire (Euro-QoL, EQ-5D) [25], and the Medical Outcomes Study 36-item Short-Form Health Survey (SF-36) [15].

The World Health Organization Quality Of Life Questionnaire (WHOQOL) was developed by a multicenter international study and includes six factors: physical condition, independence statement, mental health, social relations, spirituality/religiousness/personal beliefs, and environment [26]. A shorter version of the questionnaire was provided (WHOQOL-Bref) [27, 28].

The Nottingham Health Profile (NHP) includes two parts. The domains addressed include the bodily, intellectual, and emotional spheres, as well as the respondent’s social relationships. The score does not ignore the respondents’ accurate well-being, but mostly analyzes the poor elements in their functioning [24].

The Euro-Quality of Life Questionnaire (EuroQoL, EQ-5D) offers a questionnaire with extraordinary sensitivity to short-term changes, but the fluctuations of the effects are important, impeding use of this tool [25].

The other most commonly used questionnaires in cardiovascular diseases are the Minnesota Living with Heart Failure (MLHF) questionnaire [29] and the MacNew Heart Disease Health-Related Quality of Life Questionnaire (MacNew) [30]. The Minnesota Living with Heart Failure Questionnaire is used in the evaluation of chronic heart failure patients [29]. The MacNew Heart Disease Health-Related Quality of Life Questionnaire (MacNew) was developed as an alteration of the Quality of Life after Myocardial Infarction Questionnaire (QLMI) [30]. Its purpose is to evaluate patients after myocardial infarction or with coronary artery disease or heart failure [30].

A well-recognized HRQoL instrument is the Medical Outcomes Survey Short-Form 36 (SF-36) [31]. Studies have demonstrated that one of the most appropriate methods to assess cardiovascular diseases HRQoL is the SF-36 survey [18, 3235]. The SF-36 questionnaire was developed during the Medical Outcomes Study to evaluate the general health condition of various patient groups [15]. It is a self-administered instrument that takes about 15 minutes to complete. A Turkish version is available [13].

Anxiety was described by Freud as “something felt”, an emotional state that blanketed feelings of apprehension, tension, anxiety, and fear followed with the aid of physiological arousal. Anxiety before a surgical procedure was accepted as a vital aspect for postoperative complications. It has been also discovered that patients with a high degree of preoperative anxiety respond worse to analgesic medication than patients with a low stage of lower anxiety [36]. Among coronary heart disease patients undergoing coronary artery bypass grafting, anxiety was detected commonly and showed an association with an increased all-cause mortality risk. Although anxiety and depression was undoubtedly and particularly correlated in those patients, only anxiety was found associated with improved mortality and morbidity.

Improved quality of life has come to be one of the most critical effects of lower extremity peripheral arterial disease [3740]. The research has cautioned that the experience and recovery process after a cardiovascular operation may be more complicated than anticipated [41]. Particularly anxiety and depression seem to affect the postoperative process and specific quality of life after vascular intervention and/or surgery [42]. The reviews on the benefits of vascular surgical treatment have centered on postoperative subjective health outcomes in terms of functional status, activity level, daily life activity, return to work, psychological well-being and self-reported health-related functional status as well as objective negative cardiac events, survival and complication rates [2, 20, 42].

Despite there not having been any significant morbidity and success of vascular intervention with high graft patency, significant improvement in only two out of eight health domains – social functioning (p < 0.03) and general health perception (p < 0.04) – was found at 6-month follow-up in our series. The findings of the present study imply that most of the patients with lower preoperative HRQoL included in the study were classified as presenting clinically significant anxiety symptoms and there was no significant decrease of the levels of trait and state anxiety postoperatively. Also the education level of the series was considerably low, with a mean of 6.95 years; the majority of patients have had education to secondary school level. This findings led to the conclusion that a preoperative high level of trait anxiety continued postoperatively and affected the perception of quality of life postoperatively. The results of the present study suggest that the assessment of psychosocial factors, particularly the ongoing assessment of anxiety using trait (chronic) and state (current) STAI levels, could help in risk stratification of patients’ functional status of HRQoL but also postoperative results prediction.

Poor HRQoL and anxiety should be recognized and thoroughly considered within other positive awareness procedures [43]. The selected interventions about anxiety of patients preoperatively may have inspired the well-being after vascular surgery. Measurement of HRQoL should be considered as a routine evaluation to gain a whole picture of the patients’ situation and strengthen conclusions about the effectiveness of therapy.

There is a growing recognition of the importance of psychosocial factors in the recovery from cardiovascular surgical procedures [18]. Important predictors of advanced high-quality lifestyles consequences contain age, gender education, and comorbidities [17]. Preoperative mood and cognitive performances are also relevant predictors for early postoperative psychological dysfunctions, which might be related to extended hospitalization and mortality after a surgical operation [2].

Clinicians, patients, and relatives should be aware about this probability, and an attempt should be made at the preoperative identification of patients predisposed to severe chronic stress [37, 40, 43]. Moreover, cardiovascular surgeons need to be aware of their patients’ psychosocial functioning and, if necessary, advise them to take expert guidance and help to maximize well-being. Furthermore, the assessment of preoperative well-being should be integrated in routine care in order to identify and support patients with higher levels of anxiety for a full understanding of how peripheral vascular disease affects patients individually.

One of the limitations is that the demographic variables may have had significant interactions with the variables anxiety and HRQoL but were not included in the regression analysis. Another limitation is that the SF-36 asks patients about typical daily activities. Future studies are warranted to evaluate demographic variables and physical health status as predictors of benefits from cardiovascular surgery.

In conclusion, a patient’s operative risk as well as SF-36 and STAI scores should be assessed. Multicenter and larger studies are warranted to assess effects of different psychosocial factors on long-term mortality and morbidity.

Conflict of interest

The authors declare no conflict of interest.

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