eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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SCImago Journal & Country Rank
4/2020
vol. 45
 
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abstract:
Clinical immunology

Association between disease-related malnutrition and innate immunity gene expression in critically ill patients at intensive care unit admission

Robert Słotwiński
1
,
Aleksandra Dąbrowska
1
,
Katarzyna Kosałka
2
,
Andrzej Kański
3
,
Sylwia Małgorzata Słotwińska
4

1.
Department of Immunology, Biochemistry, and Nutrition, Medical University of Warsaw, Poland
2.
Central Clinical Hospital of the Ministry of Interior and Administration, Warsaw, Poland
3.
2nd Department of Anaesthesiology and Intensive Care, Medical University of Warsaw, Poland
4.
Department of Oral Hygiene, Medical University of Warsaw, Poland
Centr Eur J Immunol 2020; 45 (4): 414-424
Online publish date: 2021/01/30
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The aim of the study was to analyse the relationship between nutritional disorders and the expression of innate antibacterial response genes in patients admitted to the intensive care unit (ICU). In

46 patients with severe malnutrition and life-threatening surgical complications, nutritional status tests were performed on the basis of the NRS 2002 (Nutritional Risk Screening) scale, cytokine, albumin, C-reactive protein concentrations, anthropometric tests, and body composition analysis. Concurrently, the expression of Toll-like receptor 2, NOD1, TRAF6, and HMGB1 genes was determined in peripheral blood leukocytes at the mRNA level using real-time polymerase chain reaction. It was found that both the nutritional status and the gene expression changed depending on the group of patients studied (including the group of survivors vs. non-survivors). Significant correlations were found between the results of routine tests used in the diagnostics of malnutrition (including NRS 2002, resistance, reactance, phase angle, excess of extracellular water) and the expression of the studied genes. Moreover, the expression of TRAF6 and HMGB1 genes correlated with the Acute Physiology and Chronic Health Evaluation II scale and the age of the patients. The results of the research suggest that the expression of innate antibacterial response genes may be a new diagnostic tool complementing the assessment of nutritional disorders in surgical patients admitted to the ICU. These tests may be helpful in providing more accurate diagnostics of the genetic effects of malnutrition and in the monitoring of patients for whom nutritional treatment is planned to support the functions of the immune system, thereby increasing the effectiveness of this type of treatment in the ICU.
keywords:

malnutrition, gene expression, innate immunity

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