eISSN: 1896-9151
ISSN: 1734-1922
Archives of Medical Science
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SCImago Journal & Country Rank
4/2020
vol. 16
 
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Neurosurgery
abstract:
Clinical research

Association between oxidative stress biomarkers and concentrations of some metal ions in the blood of patients with brain tumors and hydrocephalus

Ljiljana Vujotić
1, 2
,
Siniša Matić
2
,
Slavica Borković-Mitić
3
,
Aleksandar Stojsavljević
4
,
Jelena Mutić
4
,
Vladimir Baščarević
1, 2
,
Miloš Joković
1, 2
,
Slađan Pavlović
3

1.
Department of Surgery, Faculty of Medicine, University of Belgrade, Belgrade, Serbia
2.
Clinical Center of Serbia, Neurosurgery Division, Belgrade, Serbia
3.
Department of Physiology, Institute for Biological Research “Siniša Stanković”, University of Belgrade, Belgrade, Serbia
4.
Faculty of Chemistry, University of Belgrade, Belgrade, Serbia
Arch Med Sci 2020; 16 (4): 811–819
Online publish date: 2019/08/22
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Introduction
Any substance that induces production of free radicals can be a potential cause of brain damage. The aim of our study was to investigate the relationship between some metal ions and oxidative stress biomarkers in the blood of patients with brain tumor and hydrocephalus.

Material and methods
Our study included 27 control subjects, 24 patients with brain tumor and 21 patients with hydrocephalus. The activities of superoxide dismutase (CuZn SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR), glutathione S-transferase (GST) and acetyl cholinesterase (AChE), as well as concentrations of reduced glutathione (GSH), lipid peroxides (TBARS) and sulfhydryl groups (SH) were analyzed in the plasma and red blood cells (RBCs) of patients. We also determined the concentrations of Mn, Ni, Co, Cu, Zn, As, Se, Cd, Hg and Fe.

Results
The higher activity of SOD and concentration of GSH in both investigated groups could indicate higher oxidative stress. We also observed decreased levels of SH groups in both groups of patients. In both groups of patients we detected decreased concentrations of Ni, Co, Zn and Fe (and Mn in brain tumor patients) and increased concentrations of As, Se and Cd in the blood. Interestingly, we observed a higher concentration of Cd in both plasma and RBCs of hydrocephalus patients compared to the patients with brain tumor.

Conclusions
There are strong correlations between some metal ion concentrations and certain oxidative stress biomarkers in the blood of patients, which supports our hypothesis, but the observed trend needs to be further investigated.

keywords:

antioxidant enzymes, trace elements, neurotoxicity redox homeostasis

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