Abstract
2/2024
vol. 75
Original paper
Association of PD-1 and PD-L1 protein expression with selected clinical and morphological parameters in colorectal cancers
- Department of Tumor Pathology, Greater Poland Cancer Centre, Poznań, Poland
- Department of Oncologic Pathology and Prophylaxis, University of Medical Sciences, Poznań, Poland
- Department of Pathology, Pomeranian Medical University, Szczecin, Poland
- Laboratory of Cancer Genetics, Greater Poland Cancer Centre, Poznań, Poland
- Research and Implementation Unit, Greater Poland Cancer Centre, Poznań, Poland
Pol J Pathol 2024; 75 (2): 105-114
Online publish date: 2024/05/27
Colorectal cancer is the third most common cancer worldwide and the second cause of death from malignant tumors. Colorectal cancers are treated with surgery, chemotherapy, gene therapy and immunotherapy. PD-1 and PD-L1 proteins have recently been considered as potential targets of anticancer therapy in colorectal cancer. The aim of this study was to evaluate the association of immunohistochemical expression of PD-1 and PD-L1 proteins in colorectal cancer patients with selected clinical and morphological parameters and their survival. Ninety-eight cases of colorectal cancer were studied.
Immunohistochemistry was used to evaluate the expression of PD-1 and PD-L1 proteins.
Correlations were found between the expression of PD-L1 protein in lymphocytes and lack of lymph node metastases and a lower clinical stage.
There was also a correlation between PD-L1 protein expression in cancer cells and a higher grade of histological malignancy.
Immunohistochemistry was used to evaluate the expression of PD-1 and PD-L1 proteins.
Correlations were found between the expression of PD-L1 protein in lymphocytes and lack of lymph node metastases and a lower clinical stage.
There was also a correlation between PD-L1 protein expression in cancer cells and a higher grade of histological malignancy.
Keywords
colorectal cancer, PD-1, PD-L1
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