eISSN: 1896-9151
ISSN: 1734-1922
Archives of Medical Science
Current issue Archive Manuscripts accepted About the journal Special issues Editorial board Abstracting and indexing Subscription Contact Instructions for authors
SCImago Journal & Country Rank
6/2018
vol. 14
 
Share:
Share:
more
 
 
abstract:
Systematic review/Meta-analysis

Association of interleukin-17a rs2275913 gene polymorphism and asthma risk: a meta-analysis

Cui Zhai, Shaojun Li, Wei Feng, Wenhua Shi, Jian Wang, Qingting Wang, Limin Chai, Qianqian Zhang, Xin Yan, Manxiang Li

Arch Med Sci 2018; 14, 6: 1204–1211
Online publish date: 2018/03/02
View full text
Get citation
ENW
EndNote
BIB
JabRef, Mendeley
RIS
Papers, Reference Manager, RefWorks, Zotero
AMA
APA
Chicago
Harvard
MLA
Vancouver
 
Introduction
Interleukin-17A (IL-17A), a pro-inflammatory cytokine, plays an important role in the pathogenesis of asthma. A number of studies have investigated the relationship between IL-17A rs2275913 polymorphism and risk of asthma. However, the results obtained are inconclusive. The aim of this meta-analysis is to clarify the relationship between IL-17A rs2275913 polymorphism and asthma risk.

Material and methods
Searches were conducted in PubMed, Web of Science, Elsevier, Google Scholar, Wanfang and Chinese National Knowledge Infrastructure (CNKI) databases, and data were extracted from eligible studies by two independent reviewers. The pooled odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were calculated. Publication bias, heterogeneity and sensitivity analysis were also assessed.

Results
Ten studies with a total of 5016 subjects were included. Overall, the results indicated a significant association between the IL-17A rs2275913 polymorphism and the risk of asthma (G vs. A: OR = 0.866, 95% CI = 0.789–0.951, p = 0.003; GG+GA vs. AA: OR = 0.752, 95% CI = 0.633–0.895, p = 0.001). In subgroup analysis by age and ethnicity, the G allele of rs2275913 in IL-17A was significantly associated with a reduced risk of asthma in children and Asians.

Conclusions
The results of this meta-analysis indicate that the G allele of rs2275913 in IL-17A is a protective factor for the development of asthma.

keywords:

IL-17A, polymorphism, asthma, risk, meta-analysis

references:
Mathew J, Aronow WS, Chandy D. State of the art paper. Therapeutic options for severe asthma. Arch Med Sci 2012; 8: 589-97.
Yan L, Xiao-Ling S, Zheng-Yan C, Guo-Ping L, Sen Z, Zhuang C. HSP70/CD80 DNA vaccine inhibits airway remodeling by regulating the transcription factors T-bet and GATA-3 in a murine model of chronic asthma. Arch Med Sci 2013; 9: 906-15.
Freidin MB, Puzyrev VP, Ogorodova LM, Kobiakova OS, Kulmanakova IM. [Polymorphism of interleukins and interleukin receptor genes: population distribution and association with atopic bronchial asthma]. Genetika 2002; 38: 1710-8.
Tam EK, Jourdan-LeSaux C, Stauder S, et al. Polymorphisms in the interleukin-4 receptor alpha chain: association with traits of allergy and asthma in an admixed population in Hawaii. Cell Mol Biol 2003; 49: 1345-9.
Heinzmann A, Bauer E, Ganter K, Kurz T, Deichmann KA. Polymorphisms of the TGF-beta1 gene are not associated with bronchial asthma in Caucasian children. Pediatr Allergy Immunol 2005; 16: 310-4.
Kacprzak D, Pawliczak R. Does aspirin-induced oxidative stress cause asthma exacerbation? Arch Med Sci 2015; 11: 494-504.
Schmidt-Weber CB, Akdis M, Akdis CA. TH17 cells in the big picture of immunology. J Allergy Clin Immunol 2007; 120: 247-54.
Nembrini C, Marsland BJ, Kopf M. IL-17-producing T cells in lung immunity and inflammation. J Allergy Clin Immunol 2009; 123: 986-94; quiz 995-6.
O’Shea JJ, Paul WE. Mechanisms underlying lineage commitment and plasticity of helper CD4+ T cells. Science (New York, NY) 2010; 327: 1098-102.
Bullens DM, Truyen E, Coteur L, et al. IL-17 mRNA in sputum of asthmatic patients: linking T cell driven inflammation and granulocytic influx? Respir Res 2006; 7: 135.
Chakir J, Shannon J, Molet S, et al. Airway remodeling-associated mediators in moderate to severe asthma: effect of steroids on TGF-beta, IL-11, IL-17, and type I and type III collagen expression. J Allergy Clin Immunol 2003; 111: 1293-8.
Maalmi H, Beraies A, Charad R, Ammar J, Hamzaoui K, Hamzaoui A. IL-17A and IL-17F genes variants and susceptibility to childhood asthma in Tunisia. J Asthma 2014; 51: 348-54.
Wang JY, Shyur SD, Wang WH, et al. The polymorphisms of interleukin 17A (IL17A) gene and its association with pediatric asthma in Taiwanese population. Allergy 2009; 64: 1056-60.
Chen J, Deng Y, Zhao J, et al. The polymorphism of IL-17 G-152A was associated with childhood asthma and bacterial colonization of the hypopharynx in bronchiolitis. J Clin Immunol 2010; 30: 539-45.
Wei B, Zhu LL, Deng DF. Association between polymorphisms in promoter region of interleukin-10 and interleukin-17 gene and childhood asthma. Progress in Modern Biomedicine 2011; 11: 307-09, 13.
Wang J, Zhou J, Lin LH, Li J, Peng X, Li L. Association of single nucleotide polymorphism of IL-17 gene promoter with childhood asthma. Academic Journal of Second Military Medical University 2011; 32: 481-4.
Narbutt J, Wojtczak M, Zalinska A, et al. The A/A genotype of an interleukin-17A polymorphism predisposes to increased severity of atopic dermatitis and coexistence with asthma. Clin Exp Dermatol 2015; 40: 11-6.
Luo S. The Polymorphism of Interleukin 17-152A and its Association with Bronchial Asthma. [Master]: Dalian Medical University; 2013.
Zeng Y, Li B, Yang J, Xia MQ, Zhu XP. Correlation study of Polyporphism of Interleukin-17A -152G/A of Childhood Asthma in Guiyang. Journal of Guiyang Medical 2015; 6: 588-91.
Du J, Han JC, Zhang YJ, et al. Single-Nucleotide Polymorphisms of IL-17 Gene Are Associated with Asthma Susceptibility in an Asian Population. Med Sci Monit 2016; 22: 780-7.
Resende EP, Todo-Bom A, Loureiro C, et al. Asthma and rhinitis have different genetic profiles for IL13, IL17A and GSTP1 polymorphisms. Rev Port Pneumol 2006; 23: 10-6.
Ma X, Wang L, Zhao H, et al. Th17 cells are associated with the Th1/Th2cell balance during Echinococcus multilocularis infection. Mol Med Rep 2014; 10: 236-40.
Yamada H. Current perspectives on the role of IL-17 in autoimmune disease. J Inflamm Res 2010; 3: 33-44.
Straus DS. TNFalpha and IL-17 cooperatively stimulate glucose metabolism and growth factor production in human colorectal cancer cells. Mol Cancer 2013; 12: 78.
Kawaguchi M, Adachi M, Oda N, Kokubu F, Huang SK. IL-17 cytokine family. J Allergy Clin Immunol 2004; 114: 1265-73; quiz 74.
Miossec P, Korn T, Kuchroo VK. Interleukin-17 and type 17 helper T cells. N Engl J Med 2009; 361: 888-98.
Newcomb DC, Peebles RS, Jr. Th17-mediated inflammation in asthma. Curr Opin Immunol 2013; 25: 755-60.
Chang Y, Al-Alwan L, Risse PA, et al. TH17 cytokines induce human airway smooth muscle cell migration. J Allergy Clin Immunol 2011; 127: 1046-53.
Chang Y, Al-Alwan L, Risse PA, Halayko AJ, Martin JG, Baglole CJ, Eidelman DH, Hamid Q. Th17-associated cytokines promote human airway smooth muscle cell proliferation. FASEB 2012; 26: 5152-60.
Laan M, Prause O, Miyamoto M, Sjöstrand M, Hytönen AM, Kaneko T, Lötvall J, Lindén A. a role of GM-CSF in the accumulation of neutrophils in the airways caused by IL-17 and TNF-alpha. Eur Respir J 2003; 21: 387-93.
Linden A. Interleukin-17 and airway remodelling. Pulm Pharmacol Therap 2006; 19: 47-50.
Fujisawa T, Velichko S, Thai P, Hung LY, Huang F, Wu R. Regulation of airway MUC5AC expression by IL-1beta and IL-17A; the NF-kappaB paradigm. J Immunol 2009; 183: 6236-43.
Chen Y, Thai P, Zhao YH, Ho YS, DeSouza MM, Wu R. Stimulation of airway mucin gene expression by interleukin (IL)-17 through IL-6 paracrine/autocrine loop. J Biology Chemistry 2003; 278: 17036-43.
Wang JY, Lin CG, Bey MS, Wang L, Lin FY, Huang L, et al. Discovery of genetic difference between asthmatic children with high IgE level and normal IgE level by whole genome linkage disequilibrium mapping using 763 autosomal STR markers. J Human Genetics 2005 50: 249-58.
Arisawa T, Tahara T, Shibata T, Nagasaka M, Nakamura M, Kamiya Y, et al. The influence of polymorphisms of interleukin-17A and interleukin-17F genes on the susceptibility to ulcerative colitis. J Clin Immunol 2008; 28: 44-9.
Li Z, Liu Y, Cao D, Jiang M, Luo F. IL-17A and IL-17F polymorphisms and gastric cancer risk: a meta-analysis. Genet Mol Res 2015; 14: 7008-17.
Espinoza JL, Takami A, Nakata K, et al. a genetic variant in the IL-17 promoter is functionally associated with acute graft-versus-host disease after unrelated bone marrow transplantation. PloS One 2011; 6: e26229.
Cookson W. The alliance of genes and environment in asthma and allergy. Nature 1999; 402: B5-11.
Wills-Karp M, Ewart SL. Time to draw breath: asthma-susceptibility genes are identified. Nat Rev Genet 2004; 5: 376-87.
Stelmach I, Majak P, Jerzyńska J, Bojo M, Cichalewski Ł, Smejda K. Letter to the Editor. Children with severe asthma can start allergen immunotherapy after controlling asthma with omalizumab: a case series from Poland. Arch Med Sci 2015; 11: 901-4.
FEATURED PRODUCTS
Quick links
© 2018 Termedia Sp. z o.o. All rights reserved.
Developed by Bentus.
PayU - płatności internetowe