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ISSN: 1734-1922
Archives of Medical Science
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vol. 15
Letter to the Editor

Association of polymorphisms of the TNFRSF11B and TNFSF11 genes with bone mineral density in postmenopausal women from western Mexico

Anahi González-Mercado
1, 2
Josefina Y. Sánchez-López
Francisco J. Perea-Díaz
Maria T. Magaña-Torres
Mario Salazar-Páramo
Laura González-López
Mirna Gisel González-Mercado
Bertha Ibarra-Cortés

Doctorado en Genética Humana, CUCS, UdeG. Guadalajara, Jalisco, México
División de Genética, CIBO, IMSS, Guadalajara, Jalisco, México
División de Investigación en Salud, UMAE-HE, CMNO, IMSS, Guadalajara, México
Servicio de Reumatología del HGR-110 IMSS, Guadalajara, México
División de Biotecnología y Salud, Tecnológico de Monterrey, Guadalajara, México
Arch Med Sci 2019; 15 (5): 1352–1356
Online publish date: 2019/08/22
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Osteoporosis (OP) is a disease with reduced bone mass and deterioration of the spatial distribution of the trabecular bone structure, leading in consequence to increased bone fragility and risk of fractures [1]. In Mexico its frequency in postmenopausal women is 8.3% to 31% [2]. OP is a multifactorial disease because its development involves physiological, environmental and genetic factors [3]. Genes of the tumor necrosis factor (TNF) family like TNFRSF11B (TNF receptor superfamily member 11b) and TNFSF11 (TNF superfamily member 11) encode for osteoprotegerin (OPG) and receptor activator for nuclear factor B ligand (RANKL) proteins, respectively, that participate in the signaling pathway OPG/RANK/RANKL, balancing the activity between osteoblasts and osteoclasts to prevent bone loss and to ensure normal bone turnover [4, 5]. Different single nucleotide polymorphisms (SNPs) in genes of this pathway are related to bone mineral density (BMD) or OP [6, 7]. In Mexican postmenopausal women, SNPs of the TNFRSF11B gene were studied but no association with BMD [8, 9] or OP [10] was observed; SNPs of the TNFSF11 gene have not been studied for OP.
The aim of this study was to investigate the association of the polymorphisms 1181 G>C (rs2073618) and 1217 C>T (rs3102734) of TNFRSF11B; as well as -708 T>A, -693 C>G (rs9533155), -657 C>A, -643 C>T (rs9533156) and -290 C>T (rs9525641) of TNFSF11 with BMD.
Five hundred and thirteen postmenopausal Mexican-Mestizo women from western Mexico agreed to participate in the study. They were recruited from Hospital General Regional No. 110 of the Instituto Mexicano del Seguro Social in Guadalajara city. BMD of the lumbar spinal L1-L4 region and of the femoral neck (left and right) was determined by means of DEXA (dual-energy X-ray absorptiometry, Prodigy Advance, GE). A hundred and seventy-four women were matched by age (range was between 42 to 69 years) and body mass index (BMI) (range from 19.7 to 42.1 kg/m2) in two groups by the WHO criteria: women with values of the T-score less than –2.5 SD (OP group, n = 87) and those with values of the T-score above -1 SD (non-OP group, n = 87). A questionnaire that included different biological (age, BMI, age at onset of menarche and menopause, family history of OP, personal and family history of fractures) and lifestyle (smoking, alcoholism, coffee consumption and sedentarism) variables was applied to all participants. This study was approved by the local ethical...

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