Polish Journal of Pathology

Full text

1/2026 vol. 77
Case report

Atypical lymph node involvement in a rare case of Kikuchi-Fujimoto disease: a case report and literature review

Jakub Stanek 1
,
Jagoda Jakubik-Stanek 2
,
Dominik Paprocki 3
,
Piotr Król 4
,
Jarosław Jakubik 1

  1. 2nd Department of Surgical Oncology, Copernicus Memorial Multi-Specialist Oncology and Trauma Center, Lodz, Poland

  2. Department of Biomedical Chemistry, Faculty of Health Sciences, Medical University of Lodz, Lodz, Poland

  3. Department of Pathology, Chair of Oncology, Medical University of Lodz, Lodz, Poland

  4. Emergency Department, Copernicus Memorial Multi-Specialist Oncology and Trauma Center, Lodz, Poland

Pol J Pathol 2026; 77 (1): 84-88

DOI: https://doi.org/10.5114/pjp.2026.161721
Data publikacji online: 2026/06/09
Article file
Atypical lymph.pdf
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  1. Masab M, Surmachevska N, Farooq H. Kikuchi-Fujimoto Disease. In: StatPearls. Treasure Island (FL): StatPearls, 2025. Available from: http://www.ncbi.nlm.nih.gov/books/NBK430830/ (accessed: 28.04.2025).
  2. Kikuchi M. Lymphadenitis showing reticulum cell hyperplasia with nuclear debris and phagocytes. Acta Hematol Jpn 1972; 53: 379-380.
  3. Pileri S, Kikuchi M, Helbron D, Lennert K. Histiocytic necrotizing lymphadenitis without granulocytic infiltration. Virchows Arch Pathol Anat Histol 1982; 395: 257-271.
  4. Bosch X, Guilabert A, Miquel R, Campo E. Enigmatic Kikuchi- Fujimoto disease: a comprehensive review. Am J Clin Pathol 2004; 122: 141-152.
  5. Pepe F, Disma S, Teodoro C, Pepe P, Magro G. Kikuchi- Fujimoto disease: a clinicopathologic update. Pathologica 2016; 108: 120-129.
  6. Fujimoto Y. Cervical subacute necrotizing lymphadenitis. Naika 1972; 30: 920-927.
  7. Lin HC, Su CY, Huang CC, Hwang CF, Chien CY. Kikuchi’s disease: a review and analysis of 61 cases. Otolaryngol Head Neck Surg 2003; 128: 650-653.
  8. Perry AM, Choi SM. Kikuchi-Fujimoto disease: a review. Arch Pathol Lab Med 2018; 142: 1341-1346.
  9. Mahajan VK, Sharma V, Sharma N, Rani R. Kikuchi-Fujimoto disease: a comprehensive review. World J Clin Cases 2023; 11: 3664-3679.
  10. Kucukardali Y, Solmazgul E, Kunter E, Oncul O, Yildirim S, Kaplan M. Kikuchi-Fujimoto disease: analysis of 244 cases. Clin Rheumatol 2007; 26: 50-54.
  11. Chong Y, Kang CS. Causative agents of Kikuchi-Fujimoto disease (histiocytic necrotizing lymphadenitis): a meta-analysis. Int J Pediatr Otorhinolaryngol 2014; 78: 1890-1897.
  12. Ifeacho S, Aung T, Akinsola M. Kikuchi-Fujimoto disease: a case report and review of the literature. Cases J 2008; 1: 187.
  13. Qadri F, Atkin GK, Thomas D, Das SK. Kikuchi’s disease: an important cause of cervical lymphadenopathy. Clin Med Lond Engl 2007; 7: 82-84.
  14. Al Ghadeer HA, AlKadhem SM, AlMajed MS, AlAmer HM, AlHabeeb JA, Alomran SH, et al. Kikuchi-Fujimoto disease following COVID-19. Cureus 2022; 14: e21049.
  15. Deaver D, Horna P, Cualing H, Sokol L. Pathogenesis, diagnosis, and management of Kikuchi-Fujimoto disease. Cancer Control J Moffitt Cancer Cent 2014; 21: 313-321.
  16. Rezai K, Kuchipudi S, Chundi V, Ariga R, Loew J, Sha BE. Kikuchi-Fujimoto disease: hydroxychloroquine as a treatment. Clin Infect Dis Off Publ Infect Dis Soc Am 2004; 39: e124-126.
  17. Lin HC, Su CY, Huang SC. Kikuchi’s disease in Asian children. Pediatrics 2005; 115: e92-96.
  18. Paradela S, Lorenzo J, Martínez-Gómez W, Yebra-Pimentel T, Valbuena L, Fonseca E. Interface dermatitis in skin lesions of Kikuchi-Fujimoto’s disease: a histopathological marker of evolution into systemic lupus erythematosus? Lupus 2008; 17: 1127-1135.
  19. Kim KJ, Jee MS, Chang SE, Choi JH, Sung KJ, Moon KC, et al. Kikuchi-Fujimoto disease with papulopustular skin manifestations. Clin Exp Dermatol 2003; 28: 142-144.
  20. Sumiyoshi Y, Kikuchi M, Takeshita M, Yoneda S, Kobari S, Ohshima K. Immunohistological study of skin involvement in Kikuchi’s disease. Virchows Arch B 1992; 62: 263-269.
  21. Yasukawa K, Matsumura T, Sato-Matsumura KC, Takahashi T, Fujioka Y, Kobayashi H, et al. Kikuchi’s disease and the skin: case report and review of the literature. Br J Dermatol 2001; 144: 885-889.
  22. Zhang WP, Wang JH, Wang WQ, Chen XQ, Wang Z, Li YF, et al. An association between parvovirus B19 and Kikuchi-Fujimoto disease. Viral Immunol 2007; 20: 421-428.
  23. Sumiyoshi Y, Kikuchi M, Minematu T, Ohshima K, Takeshita M, Minamishima Y. Analysis of herpesvirus genomes in Kikuchi’s disease. Virchows Arch Int J Pathol 1994; 424: 437-440.
  24. Hudnall SD, Chen T, Amr S, Young KH, Henry K. Detection of human herpesvirus DNA in Kikuchi-Fujimoto disease and reactive lymphoid hyperplasia. Int J Clin Exp Pathol 2008; 1: 362-368.
  25. Tan HM, Hue SSS, Wee A, See KC. Kikuchi-Fujimoto disease post COVID-19 vaccination: case report and review of literature. Vaccines 2021; 9: 1251.
  26. Daghri S, Belmoufid N, Rami A, Al Bouzidi A, Bouanani N. Kikuchi-Fujimoto’s disease or histiocytic necrotizing lymphadenitis following mRNA COVID-19 vaccination: a rare case. Cureus 2022; 14: e24155.
  27. Saito Y, Suwa Y, Kaneko Y, Tsujiwaki M, Odagawa Y. Kikuchi- Fujimoto disease following COVID-19 infection in a 7-year-old girl: a case report and literature review. Cureus 2022; 14: e26540.
  28. Eisner MD, Amory J, Mullaney B, Tierney L, Browner WS. Necrotizing lymphadenitis associated with systemic lupus erythematosus. Semin Arthritis Rheum 1996; 26: 477-482.
  29. Sharma V, Rankin R. Fatal Kikuchi-like lymphadenitis associated with connective tissue disease: a report of two cases and review of the literature. SpringerPlus 2015; 4: 167.
  30. Pileri SA, Facchetti F, Ascani S, Sabattini E, Poggi S, Pic- cioli M, et al. Myeloperoxidase expression by histiocytes in Kikuchi’s and Kikuchi-like lymphadenopathy. Am J Pathol 2001; 159: 915-924.
  31. Tong K. A Clinicopathologic study of 79 cases with an analysis of histologic subtypes, immunohistology, and DNA ploidy. Am J Surg Pathol 1995; 19: 798-809.
  32. Spies J, Foucar K, Thompson CT, le Boit PE. The histopathology of cutaneous lesions of Kikuchi’s disease (necrotizing lymphadenitis): a report of five cases. Am J Surg Pathol 1999; 23: 1040-1047.
  33. Lin H, Su C, Huang C, Hwang C, Chien C. Kikuchi’s disease: a review and analysis of 61 cases. Otolaryngol Neck Surg 2003; 128: 650-653.
  34. Hutchinson CB, Wang E. Kikuchi-Fujimoto disease. Arch Pathol Lab Med 2010; 134: 289-293.
  35. Mrówka-Kata K, Kata D, Kyrcz-Krzemieñ S, Helbig G. Kikuchi-Fujimoto and Kimura diseases: the selected, rare causes of neck lymphadenopathy. Eur Arch Otorhinolaryngol 2010; 267: 5-11.
Copyright: © 2026 Polish Association of Pathologists and the Polish Branch of the International Academy of Pathology This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (http://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
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