eISSN: 2299-0046
ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
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SCImago Journal & Country Rank
1/2021
vol. 38
 
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abstract:
Original paper

Bacteriological analysis of selected phenotypes of chronic rhinosinusitis with co-existing asthma, allergy and hypersensitivity to non-steroidal anti-inflammatory drugs

Grażyna Stryjewska-Makuch
1
,
Małgorzata A. Janik
2
,
Hanna Klamińska-Cebula
3
,
Bogdan Kolebacz
1
,
Wojciech Ścierski
4
,
Grażyna Lisowska
4

1.
Department of Laryngology and Laryngological Oncology, Independent Public Research Hospital No. 7 of the Silesian Medical University in Katowice, Upper Silesian Medical Centre, Katowice, Poland
2.
Department of Biomedical Computer Systems, Institute of Computer Science, Faculty of Computer Science and Materials Science, University of Silesia in Katowice, Sosnowiec, Poland
3.
Microbiological Laboratory, Independent Public Research Hospital No. 7, the Silesian Medical University in Katowice, Upper Silesian Medical Centre, Katowice, Poland
4.
Department of Otorhinolaryngology and Oncology in Zabrze, the Silesian Medical University in Katowice, Zabrze, Poland
Adv Dermatol Allergol 2021; XXXVIII (1): 57-62
Online publish date: 2021/03/10
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Introduction
Chronic rhinosinusitis (CRS) is one of the commonest chronic diseases. It is a systemic disease caused by many factors, including bacterial infections. There are two main types of CRS phenotypes: with polyps (CRSwNP) and without polyps (CRSsNP). Aim: Analysis of sinus mucosal microbiome in patients with CRS depending on the phenotype. Investigating a possible link between the type of bacterial flora and the coexistence of diseases present in the CRS (asthma, allergy or hypersensitivity to non-steroidal anti-inflammatory drugs (NSAIDs) as well as the number of performed operations.

Material and methods
The authors conducted a retrospective study of the bacterial flora of the nasal cavity in patients with CRS operated endoscopically from March 2016 to June 2017. The study consisted od 222 women and 248 men. On the basis of an endoscopic examination, patients were qualified for the phenotype with or without polyps. Based on the medical interview patients were divided into group with asthma, allergy, NSAID hypersensitivity, first and repeated operations. The statistical analysis was made.

Results
There is no statistically significant relationship (p = 0.8519) between the CRS penotypes. In the group with CRSsNP, a statistically significant relationship was found between the observed flora and the coexistence of asthma (p = 0.0409), a trend towards significance was also noticed in the case of allergy (p = 0.0947). There was no relationship between the flora and NSAID hypersensitivity (p = 0.7356). In the group of CRSwNP patients, no statistically significant relationship was found between the observed bacterial flora and the presence of asthma (p = 0.7393), hypersensitivity to drugs (p = 0.1509) or allergy (p = 0.7427). There is no statistical significance between the occurrence of particular flora and the multiplicity of operations in both the CRSwNP (p = 0.4609) and CRSsNP phenotypes (p = 0.2469).

Conclusions
Gram-positive cocci were equally common in CRSwNP and CRSsNP. In the CRSsNP, there was a correlation between the coexistence of asthma and allergy, and the presence of Gram-positive cocci. There was no statistical significance between the occurrence of particular flora and the multiplicity of operations in both CRS phenotypes.

keywords:

chronic rhinosinusitis, bacteriology, asthma, allergy, drug hypersensitivity

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