eISSN: 1896-9151
ISSN: 1734-1922
Archives of Medical Science
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6/2013
vol. 9
 
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abstract:

Basic research
CXCL12-G801A polymorphism modulates risk of colorectal cancer in Taiwan

Ming-Der Shi, Jing-Hsien Chen, Hsin-Te Sung, Jung-Shin Lee, Li-Yu Tsai, Hui-Hsuan Lin

Arch Med Sci 2013; 9, 6: 999–1005
Online publish date: 2013/11/29
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Introduction: The chemokine CXCL12, designated stromal cell-derived factor-1 (SDF-1), plays a significant role in many cancer metastases. Previous studies have shown that CXCL12-G801A, a single nucleotide polymorphism (SNP) in the 3' untranslated region, correlates with breast and lung cancer in Iran. The aim of this study was to evaluate the association of the gene variant CXCL12-G801A with colorectal cancer (CRC) in a Taiwanese cohort.

Material and methods: In this study, we used a denaturing high performance liquid chromatography (DHPLC) method to analyze the frequencies of CXCL12-G801A polymorphic variants between CRC patients (n = 258) and healthy controls (n = 300) in Taiwan.

Results: The SNP distribution was higher in CRC patients with TNM stage II (117/258) than healthy controls (52/300). We observed a significant increase in the G/A plus A/A genotype of the CXCL12-G801A polymorphism in CRC patients (45.35%) compared with healthy controls (17.33%). The analysis of allelic frequencies in both groups revealed that CRC patients have a higher frequency of A allele (23.45%) than healthy controls (8.67%). Furthermore, among older CRC patients, the frequency of the CXCL12-G801A genotype was significantly increased (p = 0.0148).

Conclusions: Our observations suggest that the CXCL12-G801A genotype may be associated with some clinical manifestations in CRC patients in Taiwan.
keywords:

chemokine CXCL12, single nucleotide polymorphism, colorectal cancer, genotype

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