Basic research
Polyunsaturated fatty acids augment tumoricidal action of 5-fluorouracil on gastric cancer cells by their action on vascular endothelial growth factor, tumor necrosis factor-α and lipid metabolism related factors
 
More details
Hide details
 
Submission date: 2014-04-14
 
 
Final revision date: 2014-05-23
 
 
Acceptance date: 2014-05-25
 
 
Online publication date: 2015-04-23
 
 
Publication date: 2015-04-30
 
 
Arch Med Sci 2015;11(2):282-291
 
KEYWORDS
TOPICS
ABSTRACT
Introduction: Gastric cancer is the second most common cause of cancer-related mortality worldwide. 5-fluorouracil (5-FU) is a commonly used anti-cancer drug. Various polyunsaturated fatty acids (PUFAs) are known to have tumoricidal action both in vitro and in vivo. Though PUFAs are known to augment the cytotoxic action of anti-cancer drugs, the exact mechanism is not clear.
Material and methods: The human gastric cancer cell line MGC (undifferentiated) and human gastric cancer cell line SGC (semi-differentiated) were either 5-FU alone or a combination of 5-FU + PUFAs and their proliferation, and ability to secrete tumor necrosis factor-α (TNF-α) and vascular endothelial growth factor (VEGF) and lipid metabolism-related factors lipoprotein lipase (LPL), peroxisome proliferator-activated-γ (PPAR-γ), and CCAAT enhancer-binding protein (C/EBP) were investigated and analyzed.
Results: It was noted that combined treatment of 5-FU + PUFAs on gastric carcinoma (MGC and SGC) cells produced a significant growth inhibitory action compared with either agent alone by inhibiting the production of TNF-α and VEGF and a simultaneous increase in the expression of LPL, PPAR-γ, and C/EBP.
Conclusions: Based on the results of the present study, it is concluded that PUFAs enhance the tumoricidal action of the anti-cancer drug 5-FU by acting on anti-angiogenic factors and enzymes involved in lipid metabolism.
eISSN:1896-9151
ISSN:1734-1922
Journals System - logo
Scroll to top