Bachurska S, Staykov D, Belovezhdov V, et al. Bilateral pheochromocytoma/intra-adrenal paraganglioma in von Hippel-Lindau patient causing acute myocardial infarction. Polish Journal of Pathology. 2014;65(1):78-82. doi:10.5114/pjp.2014.42675.
APA
Bachurska, S., Staykov, D., Belovezhdov, V., Sasano, H., Gulinac, M., & Stefanov, C. et al. (2014). Bilateral pheochromocytoma/intra-adrenal paraganglioma in von Hippel-Lindau patient causing acute myocardial infarction. Polish Journal of Pathology, 65(1), 78-82. https://doi.org/10.5114/pjp.2014.42675
Chicago
Bachurska, Svitlana, Dmitriy Staykov, Veselin Belovezhdov, Hironobu Sasano, Milena Gulinac, Chavdar Stefanov, and Hartmut P.H. Neumann. 2014. "Bilateral pheochromocytoma/intra-adrenal paraganglioma in von Hippel-Lindau patient causing acute myocardial infarction". Polish Journal of Pathology 65 (1): 78-82. doi:10.5114/pjp.2014.42675.
Harvard
Bachurska, S., Staykov, D., Belovezhdov, V., Sasano, H., Gulinac, M., Stefanov, C., and Neumann, H. (2014). Bilateral pheochromocytoma/intra-adrenal paraganglioma in von Hippel-Lindau patient causing acute myocardial infarction. Polish Journal of Pathology, 65(1), pp.78-82. https://doi.org/10.5114/pjp.2014.42675
MLA
Bachurska, Svitlana et al. "Bilateral pheochromocytoma/intra-adrenal paraganglioma in von Hippel-Lindau patient causing acute myocardial infarction." Polish Journal of Pathology, vol. 65, no. 1, 2014, pp. 78-82. doi:10.5114/pjp.2014.42675.
Vancouver
Bachurska S, Staykov D, Belovezhdov V, Sasano H, Gulinac M, Stefanov C et al. Bilateral pheochromocytoma/intra-adrenal paraganglioma in von Hippel-Lindau patient causing acute myocardial infarction. Polish Journal of Pathology. 2014;65(1):78-82. doi:10.5114/pjp.2014.42675.
A 26-year-old male presented to the emergency department complaining of obstipation, severe headache and abdominal pain. An autopsy revealed bilateral pheochromocytoma and acute myocardial infarction. The tumor cells showed positive immunoreactivity of both chromogranin A and synaptophysin and were negative for adrenocortical markers such as SF-1, c17, scc, 3-HSD as well as SDHB, suggesting a germline mutation of the gene SDHB or SDHD. Molecular genetic analyses did not show a mutation in these two genes, but a mutation in the VHL gene, in exon 3: VHL c.499C>T. This is a missense mutation and causes an amino acid change (Arg167Trp).
Keywords
von Hippel-Lindau disease, pheochromocytoma, myocardial infarction, autopsy
