ISSN: 2451-0637
Archives of Medical Science - Civilization Diseases
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1/2022
vol. 7
 
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abstract:
Clinical research

Borelis Pro phytomedicine for the complex treatment of Lyme borreliosis in children

Svitlana Oleksiivna Nykytyuk
1
,
Svitlana Mykhailivna Marchyshyn
2
,
Sergiy Ivanovuch Klymnyuk
3
,
Mariia Ivanivna Shkilna
4
,
Sofia Sergiivna Levenets
1

1.
Department of Children’s Diseases and Pediatric Surgery, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine
2.
Pharmacognosy with the Medical Botany Department, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine
3.
Department of Microbiology, Virology and Immunology, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine
4.
Department of Infectious Diseases, Epidemiology and Dermatovenereology, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine
Arch Med Sci Civil Dis 2022; 7: e33–e36
Online publish date: 2022/09/29
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Introduction
Lyme disease, also known as Lyme borreliosis (LB) (tick (Ixodes)borne borreliosis) is a transmissible, natural-focal disease characterized by damage of the skin, nervous system, heart.

Material and methods
Under observation were 68 children – residents of Ternopil region, who applied to Ternopil Regional Children Hospital, and whose age range was 8–17 years. Two schemes of complex treatment of patients were tested: the 1st – patients received Doxycycline (Unidox Solutab®), tablets 100 mg, 10 pcs. 2 time/day after meals for 14 days at a dose 4 mg/ kg; the 2nd – patients received the treatment regimen like the 1st group and phytomedicine “Boreliss pro” capsules, 28.56g, 60 pcs. (Duo Life Boreliss Pro., Poland) 1 capsule 2 time/day after meals for 14 days.

Results
Results showed that was significantly (p < 0.05) lower severity of LB in patients who received antibacterial therapy in combination with doxycycline hydrochloride and phytomedicine “Boreliss pro” (1 caps. 2 times/day, after meals), compared with individuals in another group, on the 30th day after treatment. Complex therapy of patients by phytomedicine “Boreliss pro” causes a decrease of pro-inflammatory levels of cytokines IL-1β in the serum.

Conclusions
Comprehensive treatment of patients with an erythematous form of LB by phytomedicine “Boreliss pro” contributes to a significantly (p < 0.05) faster disappearance of clinical manifestations of LB, shortening the duration of doxycycline hydrochloride use, and reducing the likelihood of side effects from this drug.

keywords:

Lyme borreliosis, doxycycline hydrochloride, Boreliss pro

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