STATE OF THE ART PAPER
Botulinum toxin A in the treatment of Raynaud’s phenomenon: a systematic review
 
More details
Hide details
 
Submission date: 2014-07-29
 
 
Final revision date: 2014-08-07
 
 
Acceptance date: 2014-08-13
 
 
Online publication date: 2015-01-08
 
 
Publication date: 2016-06-30
 
 
Arch Med Sci 2016;12(4):864-870
 
KEYWORDS
TOPICS
ABSTRACT
Introduction: The management of Raynaud’s phenomenon in its most severe form is challenging, and current medical and surgical treatment methods frequently do not lead to optimal symptom control and prevention of ischemic complications. The aim of the study was to critically evaluate all existing evidence on the use of botulinum toxin A in the management of Raynaud’s phenomenon.
Material and methods: We adopted the PRISMA methodology and searched Cochrane Library, MEDLINE, SCOPUS, EULAR and ACR congresses abstract archives for Raynaud* AND botulinum toxin OR onabotulinum. All studies that contained reports of botulinum toxin A use and its outcome in Raynaud’s phenomenon were included in the review.
Results: Eleven studies met our inclusion criteria and involved a total of 125 patients. Two reviewers extracted data from the studies under review and achieved a consensus in their selection. The main outcomes measured were pain reduction and healing of digital ulcers. The level of evidence across studies was very low to moderate.
Conclusions: There is insufficient evidence to assess the efficacy of botulinum toxin A in Raynaud’s phenomenon. Despite many promising reports, further research in the form of randomized controlled trials is warranted in order to investigate this new treatment method for Raynaud’s phenomenon.
eISSN:1896-9151
ISSN:1734-1922
Journals System - logo
Scroll to top