eISSN: 2084-9869
ISSN: 1233-9687
Polish Journal of Pathology
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2/2019
vol. 70
 
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abstract:
Original paper

CD11c- and CD123-positive dendritic cells in development of antitumour immunity in non-small cell lung cancer patients

Plamen Minkov
,
Maya Gulubova
,
Koni Ivanova
,
Evelin Obretenov
,
Julian Ananiev

Pol J Pathol 2019; 70 (2): 109-114
Online publish date: 2019/09/03
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Our aim was to analyzed the significance of CD11c and CD123 positive DCs and their relations with some clinical and pathologic parameters of patients with non-small cell lung cancer (NSCLC).

The immunohistochemical expression of CD11c and CD123, was evaluated in 40 patients with NSCLC.

After analysis we found that 35.3% of the patients in the T3-4 tumour stage had a high CD11c infiltration in the tumour stroma, while 100% of the patients in the T1-2 tumour stage had low infiltration (p = 0.03). We also found that 71.4%

of patients in the M1 stage had a high infiltration with CD123 in the tumour stroma, whereas only 15.6% of patients without metastases had high infiltration, analogous data are also found in comparing the distribution of CD123 in the tumour border (p = 0.002 or p = 0.002). Comparing the density of CD123 in the border of lymph node involvement, we found that only 7.14% of patients without metastases had low infiltration with dendritic cells, whereas in patients with metastatic lymph nodes that percentage was 41.7% (p = 0.008).

In conclusion results suggest that CD11c- and CD123-positive DCs play an important role in antitumour immunity and can be predictive factor for tumour development in patients with NSCLC.
keywords:

NSCLC, dendritic cells, CD11c, CD123

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