eISSN: 2299-0046
ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
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SCImago Journal & Country Rank
6/2021
vol. 38
 
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abstract:
Original paper

CD123 immunoexpression in cutaneous lupus erythematosus, polymorphous light eruption, pityriasis rosea, and mycosis fungoides

Ebru Karagun
1
,
Mehmet Gamsizkan
2
,
Seyma Buyucek
2
,
Sinem Coskun
2

1.
Department of Dermatology, Istinye University, School of Medicine, İstanbul, Turkey
2.
Department of Pathology, Duzce University, School of Medicine, Duzce, Turkey
Adv Dermatol Allergol 2021; XXXVIII (6): 994-1000
Online publish date: 2022/01/07
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Introduction
CD123-positive plasmacytoid dendrocytes are prominent in the infiltrate of cutaneous lupus erythematous.

Aim
To determine the significance of the CD123 immunostain, which labels plasmacytoid dendritic cells (PDC), in cutaneous lupus erythematous (CLE), polymorphous light eruption (PLE), pityriasis rosea (PR) and mycosis fungoides (MF).

Material and methods
A total of 76 cases, including MF (n = 27), CLE (n = 19), PR (n = 19), and PLE (n = 11), were included in the study after reviewing their diagnostic clinical features and pathologic findings. The primary antibody against CD123 was performed in all cases.

Results
CD123+ immunostaining in PDCs was positive in all cases. The highest mean percentage was noted in CLE (15.2%), followed by PLE (15%), PR (8.8%), and MF (2%). Besides, the clustering of CD123-positive cells was significant in CLE and PLE compared to MF and PR.

Conclusions
PDC may have an important role in the aetiology of PLE and CLE cases. CD123 is a useful marker for differentiating CLE and PLE from MF and PR.

keywords:

CD123, cutaneous lupus erythematous, light eruption, mycosis fungoides, pityriasis rosea

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