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Archives of Medical Science
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vol. 14
Clinical research

Can we define migraine patients with blood high-sensitivity C-reactive protein and galectin-3 levels in the emergency department?

Mehtap Gürger, Metin Atescelik, Mustafa Yılmaz, Mustafa Yildiz, Hatice Kalayci, Mehmet Ali Kobat, Caner Fevzi Demir

Arch Med Sci 2018; 14, 2: 307–312
Online publish date: 2016/06/30
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Introduction: Migraine, the most widespread cause of headache in young adults, is a frequent reason for presentation to emergency departments. The aim of this study was to determine the diagnostic value of serum galectin-3 and high-sensitivity C-reactive protein (hsCRP) levels in migraine patients.

Material and methods: Serum galectin-3 and hsCRP levels were measured using enzyme-linked immunosorbent assay in 70 migraine patients and 70 healthy control subjects.

Results: The mean values of hsCRP and galectin-3 levels were significantly higher in the migraine group than those in the control group (1.67 0.49, 1.12 0.38 mg/l, p < 0.001; and 3.76 1.45, 2.05 0.29 ng/ml, p < 0.001, respectively). When the diagnostic values of the biomarkers were assessed in the migraine attack and control groups, the sensitivity and specificity of the test for hsCRP at the cut-off point of 1.32 mg/l were 70% and 73% (AUC = 0.805, 95% CI: 0.74–0.88, p < 0.001), and for galectin-3 at the cut-off point of 2.4 ng/ml, 89% and 90% (AUC = 0.97, 95% CI: 0.95–0.99, p < 0.001), respectively.

Conclusions: This study showed the presence of a relation between high serum levels of hsCRP and galectin-3 in migraine patients. However, well-controlled, carefully executed longitudinal studies are required to confirm these findings.

galectin-3, high-sensitivity C-reactive protein, migraine

Gelfand AA, Goadsby PJ. A neurologist’s guide to acute migraine therapy in the emergency room. Neurohospitalist 2012; 2: 51-9.
Nijjar SS, Pink L, Gordon AS. Examination of migraine management in emergency departments. Pain Res Manage 2011; 16: 183-6.
Insinga RP, Ng-Mak DS, Hanson ME. Costs associated with outpatient, emergency room and inpatient care for migraine in the USA. Cephalalgia 2011; 31: 1570-5.
Maizels M. Headache evaluation and treatment by primary care physicians in an Emergency Department in the era of triptans. Arch Intern Med 2001; 161: 1969-73.
Torelli P, Campana V, Cervellin G, Manzoni GC. Management of primary headaches in adult Emergency Departments: a literature review, the Parma ED experience and a therapy flow chart proposal. Neurol Sci 2010; 31: 545-53.
Bounes V, Edlow JA. Migraine: diagnosis and pharmacologic treatment in Emergency Department. Eur Rev Med Pharmacol Sci 2011; 15: 215-21.
Minen MA, Tanev K, Friedman BW. Evaluation and treatment of migraine in the Emergency Department: a review. Headache 2014; 54: 1131-45.
Shin T. The pleiotropic effecet of galectin-3 in neuroinflammation: a review. Acta Histochemica 2013; 115: 407-11.
Fermino ML, Polli CD, Toledo KA, et al. LPS-induced galectin-3 oligomerization results in enhancement of neutrophil activation. PLoS One 2011; 6: e 26004.
Baseras B, Gaida MM, Kahle N, et al. Galectin-3 inhibits the chemotaxis of human polymorphonuclear neutrophils in vitro. Immunobiology 2012; 217: 83-90.
Güldiken S, Guldiken B, Demir M, et al. Soluble CD40 and prolactin levels in migraine patients during interictal period. J Headache Pain 2011; 12: 355-60.
Kuo HS, Yen CJ, Chang CH, Kuo CK, Chen JH, Sorond F. Relation of C-reactive protein to stroke, cognitive disorders, and depression in the general population: systematic review and meta-analysis. Lancet Neurol 2005; 4: 371-80.
Tietjen GE, Herial NA, White L, Utley C, Kosmyna JM, Khuder SA. Migraine and biomarkers of endothelial activation in young women. Stroke 2009; 40: 2977-82.
Vanmolkot FH, de Hoon JN. Increased C-reactive protein in young adult patients with migraine. Cephalgia 2007; 27: 843-46.
Salehi H, Aminianfar M, Naenni AR, Saidi A, Rastgoo F. Comparison of serum CRP in migraine sufferers and normal population. Zahedan J Res Med Sci 2014; 16: 13-6.
Welch KMA, Brandes AW, Salerno L, Brandes JL. C-reactive protein may be increased in migraine patients who present with complex clinical features. Headache 2006; 46: 197-9.
Avci AY, Lakadamyali H, Arikan S, Benli US, Kilinc M. High sensitivity C-reactive protein and cerebral white matter hyperintensities on magnetic resonance imaging in migraine patients. J Headache Pain 2015; 16: 9.
Tanik N, Celikbilek A, Metin A, Gocmen AY, Inan LE. Retinol-binding protein-4 and hs-CRP levels in patients with migraine. Neurol Sci 2015; 36: 1823-7.
Lippi G, Mattiuzzi C, Cervellin G. C-reactive protein and migraine. Facts or speculations? Clin Chem Lab Me 2014; 52: 1265-72.
Gudmundsson LS, Aspelund T, Scher AI, et al. C-reactive protein in migraine sufferers similar to that of nonmigraineurs: The Reykjavik Study. Cephalgia 2009; 29: 1301-10.
Yücel Y, Tanriverdi H, Arıkanoglu A, et al. Increased fibrinogen, D-dimer and galectin-3 levels in patients with migraine. Neurol Sci 2014; 35: 545-9.
Headache Classification Committee of the İnternational Headache Society (IHS). The International Classification of Headache Disorders, 3rd edition (beta version). Cephalalgia 2013; 33: 629-808.
Zhang X, Burstein R, Levy D. Local action of the proinflammatory cytokines IL-1B and IL-6 on intracranial meningeal nociceptors. Cephalgia 2011; 32: 66-72.
Scheff NN, Gold MS. Sex differencesin the inflammatory mediator-induced sensitization of dural afferents. J Neurophysiol 2011; 106: 1662-8.
Levy D, Burstein R, Strassman AM. Mast cell in the pathophsiology of migraine headache: a hypothesis. Headache 2006; 46: 13-8.
Henderson NC, Sethi T. The regulation of inflammation by galectin-3. Immunol Rev 2009; 230: 160-71.
De Boer RA, Verweij N, van Veldhuisen DJ, et al. A genome-wide assocation study of circulating galectin-3. PLoS One 2012; 7: e47385.
Ge XN, Ha SG, Liu FT, Roa SP, Sriramarao. Eosinophil-expressed galectin-3 regulates cell trafficking and migration. Front Pharmacol 2013; 4: 37.
Ertek S, Cicero A. Impact of physical activity on inflammation: effects on cardiovascular disease risk and other inflammatory conditions. Arch Med Sci 2012; 8: 794-804.
Valade D, Lucas C, Calvel L, et al. Migraine diagnosis and management in general emergency departments in France. Cephalalgia 2010; 31: 471-80.
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