eISSN: 1896-9151
ISSN: 1734-1922
Archives of Medical Science
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6/2020
vol. 16
 
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Cardiology
abstract:
Clinical research

Cardiovascular risk factors among cancer patients qualified for systemic treatment. Analysis of a cardiovascular disease-free cohort from the Polish multicentre study ONCOECHO

Marta Nowakowska
1
,
Edyta Płońska-Gościniak
2
,
Andrzej Szyszka
3
,
Łukasz Chrzanowski
1
,
Magdalena Krakowska
4
,
Piotr Potemski
4
,
Katarzyna Mizia-Stec
5
,
Zbigniew Gąsior
5
,
Artur Bodys
6
,
Maciej Siński
7
,
Adrianna Gościńska-Szmagała
8
,
Piotr Gościniak
9
,
Monika Różewicz
10
,
Beata Zaborska
11
,
Wojciech Braksator
12
,
Dariusz Kosior
13
,
Jaroslaw D. Kasprzak
1

1.
Department of Cardiology, Medical University of Lodz, Lodz, Poland
2.
Department of Cardiology, Pomeranian Medical University, Szczecin, Poland
3.
Department of Cardiology, Poznan University of Medical Sciences, Poznan, Poland
4.
Chemotherapy Clinic, Oncology Department, Medical University of Lodz, Copernicus Memorial Hospital, Lodz, Poland
5.
Department of Cardiology, Silesian Medical University, Katowice, Poland
6.
Department of Cardiology, Stefan Cardinal Wyszynski Regional Hospital, Lublin, Poland
7.
Department of Internal Medicine, Hypertension and Angiology, Medical University of Warsaw, Warsaw, Poland
8.
American Heart of Poland, Tychy, Poland
9.
Independent Laboratory of Non-Invasive Heart Diagnostics for Children and Adults, Independent Public Clinical Hospital No. 1, Pomeranian Medical University, Szczecin, Poland
10.
Department of Congenital Cardiac Defects, The Cardinal Stefan Wyszynski Institute of Cardiology, Warsaw, Poland
11.
Department of Cardiology, Centre of Postgraduate Medical Education, Warsaw, Poland
12.
Department of Sports Cardiology and Noninvasive Cardiac Diagnosis, Medical University of Warsaw, Warsaw, Poland
13.
Department of Cardiology and Hypertension, Central Clinical Hospital of Ministry of the Interior and Administration, Warsaw, Poland
Arch Med Sci 2020; 16 (6): 1295–1303
Online publish date: 2020/11/02
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Introduction
Cancer therapies are currently more efficient at increasing the survival of patients (pts) with cancer. Unfortunately, the cardiovascular (CV) complications of cancer therapies may adversely affect improving results of treatment. The aim of the study was to evaluate the prevalence of classical CV risk factors among pts with de novo diagnosis of cancer and thus identify the cohort of pts with potentially increased future risk of CV complications.

Material and methods
The analysis is based on the database of the multicentre ONCOECHO study. Pts before systemic treatment (chemotherapy or targeted therapy) were included. The diagnostic datasets of resting electrocardiogram, blood samples, and transthoracic echocardiogram were analysed in 343 consecutive pts who were free from any cardiovascular disease that could adversely affect the introduced treatment.

Results
Our cohort included 4.4% of pts with kidney cancer, 7.3% with colorectal cancer, 26.5% with haematological malignancies (HM), and 61.8% with breast cancer. The risk estimated by SCORE was 4.56 ±5.07%. Breast cancer pts had lower cardiovascular risk than those with HM (p = 0.001) and kidney cancer (p = 0.002). Additionally, the HM group had much higher levels of natriuretic peptides (p < 0.001) and creatinine (p = 0.008) than pts with breast cancer. The comparison with the NATPOL population data showed that our pts were more often smokers, hypertensives, and diabetics, but less frequently presented with hypercholesterolaemia.

Conclusions
Patients with new diagnosis of cancer, who are candidates for potentially cardiotoxic medical treatment, have increased prevalence of significant cardiovascular risk factors and therefore should be followed by a multidisciplinary team during the therapeutic process.

keywords:

cardiotoxicity, neoplasms, patient care team

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