Cariprazine – more than just a treatment for negative symptoms of schizophrenia

Małgorzata Urban-Kowalczyk

doi:10.5114/fpn.2025.154940

eISSN: 2449-9315
ISSN: 1234-8279

Pharmacotherapy in Psychiatry and Neurology/Farmakoterapia w Psychiatrii i Neurologii

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1/2025
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abstract:

Review article

Cariprazine – more than just a treatment for negative symptoms of schizophrenia

Małgorzata Urban-Kowalczyk

¹

University Clinical Center of the Medical University of Lodz

Farmakoterapia w Psychiatrii i Neurologii 2025, 41 (1), 33-41

DOI: https://doi.org/10.5114/fpn.2025.154940

Online publish date: 2025/10/30

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Objectives
This article aims to review the scientific evidence on the use of cariprazine in the treatment of negative symptoms and other domains of psychopathology.

Literature review
Treatment outcomes in schizophrenia remain suboptimal for many patients. Addressing specific symptom domains beyond the general symptomatology of schizophrenia may lead to significant functional improvement and substantially enhance the quality of life for both patients and caregivers.

Conclusions
Cariprazine, a partial agonist of dopamine D2/D3 receptors, has shown efficacy across multiple symptom domains in clinical trials, particularly in addressing negative symptoms. It appears to be a promising therapeutic option for certain patient groups. However, further research and robust scientific evidence are needed to confirm its effectiveness across broader contexts.

keywords:

Cariprazine – more than just a treatment for negative symptoms of schizophrenia

Małgorzata Urban-Kowalczyk 1

affective symptoms, cognitive impairment, secondary negative symptoms, schizophrenia

Małgorzata Urban-Kowalczyk

¹