eISSN: 2084-9869
ISSN: 1233-9687
Polish Journal of Pathology
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SCImago Journal & Country Rank
2/2015
vol. 66
 
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abstract:

Case report
Extracardiac rhabdomyomas – presentation of two cases with analysis of AKT/mTOR and ERK1/2 signaling

Ewa Iżycka-Świeszewska
,
Wojciech Wesołowski
,
Blanka Hermann

Pol J Pathol 2015; 66 (2): 195-199
Online publish date: 2015/07/28
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Extracardiac rhabdomyomas (RM) are very rare benign tumors with a poorly understood pathogenesis. In this report we describe two RM cases – a sublingual adult type tumor and a genital type tumor involving the uterine cervix. The patho-clinical characteristics, as well as the pioneer immunohistochemical analysis of ERK1/2 and AKT/mTOR pathway status is included. The expression of key proteins involved in above signaling gives new insight into the biology of extracardiac RM.
keywords:

rhabdomyoma, cellular signaling, AKT/mTOR, extracardiac

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