Posterior reversible encephalopathy syndrome (PRES) is a neurotoxic and neurometabolic state associated with a distinct appearance in neuroimaging as well as particular clinical features. While PRES is defined as a reversible condition, studies concerning the post-acute neurocognitive symptoms are not sufficient. We report a case of PRES with associated cognitive and behavioural deficits. Neuroimaging revealed bilateral abnormalities within the cerebellum, the parietal and occipital lobes, along with mild involvement of the frontal lobes. Despite the regression of these changes, results from neuropsychological examinations revealed a long-lasting mild impairment mostly affecting spatial-perceptual functions and attention, but also aspects of executive function. This case documents long-term cognitive and behavioural consequences of PRES generally corresponding with the areas implicated on neuroimaging.