A case is described of a 59-year-old woman, who after oral intake of cefaclor presented with toxic epidermal necrolysis (TEN). Toxic epidermal necrolysis is characterized by widespread erythematous and bullous lesions on the skin caused by keratinocyte necrosis leading to exfoliation of epidermis, formation of erosions on mucous membranes and reactions from other organs. In the case of TEN diagnosis local lesions involve >30% of the body surface area. Appropriate local treatment with hydrogel dressings resulted in total healing of the area of exfoliated epidermis.