eISSN: 1896-9151
ISSN: 1734-1922
Archives of Medical Science
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6/2020
vol. 16
 
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Cardiology
abstract:
Research letter

Changes in circulating stem cells and endothelial progenitor cells over a 12-month period after implantation of a continuous-flow left ventricular assist device

Peter Ivak
1, 2, 3
,
Ivan Netuka
1, 3
,
Ivana Kralova-Lesna
1, 4
,
Peter Wohlfahrt
1
,
Jan Pitha
1, 5

1.
Institute for Clinical and Experimental Medicine, Prague, Czech Republic
2.
Department of Physiology, Third Faculty of Medicine, Charles University, Prague, Czech Republic
3.
Second Department of Surgery, Department of Cardiovascular Surgery, First Faculty of Medicine, Charles University, Prague, Czech Republic
4.
Department of Anesthesiology and Intensive Care Medicine, First Faculty of Medicine, Charles University and Military University Hospital, Prague, Czech Republic
5.
Department of Internal Medicine, Second Faculty of Medicine, Charles University, Czech Republic
Arch Med Sci 2020; 16 (6): 1440–1443
Online publish date: 2020/11/02
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Introduction
Changes in circulating CD34+CD45low stem cells (SC) and CD34+CD45low+KDR+ endothelial progenitor cells (EPC) may reflect pathological endothelial activation. Non-pulsatile/continuous-flow left ventricular assist devices (CF-LVAD) can enhance this process. The aim of this study was to analyse the impact of 12-month CF-LVAD treatment on SC and EPC.

Methods
We analysed changes in SC and EPC from the pre-implantation period up until 12 months after implantation over 3-month intervals in 14 patients. Data from 12 patients with heart failure (HF) and from 13 healthy volunteers were used as controls.

Results
Baseline EPC were significantly higher in CF-LVAD and HF patients than in healthy controls, substantially decreasing 3 months after CF-LVAD implantation and then returning to high baseline values at 12 months.

Conclusions
Changes in circulating SC and EPC may reflect pathological endothelial activation after CF-LVAD implantation.

keywords:

mechanical circulatory support, continuous flow, endothelial damage, stem cells, endothelial progenitor cells

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