en POLSKI
eISSN: 2084-9834
ISSN: 0034-6233
Reumatologia/Rheumatology
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6/2021
vol. 59
 
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abstract:
Original paper

Clinical and laboratory profile of systemic lupus erythematosus patients at a rural tertiary centre in South-South Nigeria: experience from a new rheumatology clinic

Airenakho Emorinken
1
,
Mercy Ofunami Dic-Ijiewere
1
,
Cyril Oshomah Erameh
1
,
Asuwemhe Johnson Ugheoke
1, 2
,
Oluwaseun Remi Agbadaola
1
,
Folasade Ojuolape Agbebaku
1

1.
Department of Medicine, Irrua Specialist Teaching Hospital, Edo State, Nigeria
2.
Department of Medicine, Ambrose Alli University, Ekpoma, Edo State, Nigeria
Reumatologia 2021; 59, 6: 402–410
Online publish date: 2021/12/09
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Introduction
Systemic lupus erythematosus (SLE) is an autoimmune disorder with a poorly understood aetiology. It predominantly affects females and has a variety of clinical manifestations. In Nigeria, there are limited data on the prevalence and burden of the disease. This study aimed to determine the clinical and laboratory profiles of SLE patients seen in a new rheumatology clinic in South-South Nigeria.

Material and methods
This was a retrospective cross-sectional study conducted over five years (January 2016 to December 2020). The case files of patients that satisfied the diagnosis of SLE were reviewed. The diagnosis was based on the 1997 update of the American College of Rheumatology revised criteria for the classification of SLE. The sociodemographic, clinical, and immunological data were extracted from case records. Data analysis was carried out using IBM SPSS statistics® 2012 version 21.0.

Results
Fifty-two patients were diagnosed with SLE, giving a frequency of 4.7%. Forty-seven (90.4%) of the study participants were females, with a female-to-male ratio of 9.4 : 1. The mean age of the study group was 28.42 years. The mean duration of disease before diagnosis was 4.04 months with a range of 1–15 months. The patients had various organ system manifestations, with polyarthritis being the commonest (86.5%). Others included mucocutaneous (78.8%), haematological (69.2%), serositis (40.4%), renal (38.5%), and neurological (25%) manifestations. Antinuclear antibody (ANA) assay and anti-double-stranded DNA were positive in 100% and 69.2% of patients, respectively. All patients were placed on steroids, and 96.2% had hydroxychloroquine. None of the patients were on biologic disease-modifying antirheumatic drugs.

Conclusions
This study’s results are consistent with data from other African countries. To fully understand the burden and epidemiology of SLE in Nigeria, a larger prospective study is needed.

keywords:

systemic lupus erythematosus, autoantibody, clinical and laboratory profile







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