eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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3/2014
vol. 39
 
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abstract:

Clinical immunology
CD4+CD25high, CD8+CD28– cells and thyroid autoantibodies in breast cancer patients

Oğuz Bilgi
,
Bülent Karagöz
,
Orhan Türken
,
Mustafa Gültepe
,
Alpaslan Özgün
,
Tolga Tunçel
,
Levent Emirzeoğlu
,
Serkan Èçelik
,
Tuba Müftüoğlu
,
Emin Gökhan Kandemir

(Centr Eur J Immunol 2014; 39 (3): 338-344)
Online publish date: 2014/10/14
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Aim of the study: To investigate the percentage of CD4+CD25high cells (including Treg cells) and CD8+CD28– cells in breast cancer patients with and without high levels of autoimmune thyroid antibodies.

Material and methods: Thirty-five women with breast cancer (9 of them having high thyroid antibodies) and fourteen healthy subjects were enrolled in this study. Flow cytometry was used to count CD4+CD25high cells and CD8+CD28– suppressive cells (CD8 cell subtypes).

Results: In the patient group, the percentage of CD28– cells in CD8+ lymphocytes were higher [67.50% (55.11­80.33) vs. 51.56% (42.57­66.38); p = 0.021] and the percentage of CD28+CD45RO– cells (memory cells) in CD8+ lymphocytes were lower than in the control group. CD4+CD25high cell percentage in CD4+ lymphocytes was elevated in the patient group [6.44% (4.52­8.74) vs. 2.97% (1.72­4.34); p < 0.001]. When the cytometric parameters were compared between patients (with high vs. normal thyroid antibodies), the distribution of CD8+ cell subgroups was also similar. CD4+CD25high cells among CD4+ lymphocytes were decreased in patients with high levels of thyroid antibodies [5.19% (3.42­6.17) vs. 6.99% (4.82­9.95); p = 0.043].

Conclusions: CD4+CD25high cells may play a role in autoimmunity of breast cancer patients, and may be a predictive marker. Advanced studies which evaluate the possible links between regulatory cells and autoimmunity should be established in cancer patients.
keywords:

breast cancer, Treg cells, autoimmunity, thyroid antibody

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