eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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2/2014
vol. 39
 
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abstract:

Clinical immunology
Hypomethylation of interleukin 6 correlates with renal involvement in systemic lupus erythematosus

Chun Tang
,
Yun Li
,
Xiaojun Lin
,
Jinghua Ye
,
Weinian Li
,
Zhixiang He
,
Fangfei Li
,
Xiaoyan Cai

(Centr Eur J Immunol 2014; 39 (2): 203–208)
Online publish date: 2014/06/27
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Objective: To analyze peripheral blood interleukin 6 (IL-6) methylation status and its clinical significance in patients with systemic lupus erythematosus (SLE).

Material and methods: Blood samples from 41 adult patients with SLE, and 20 healthy controls were collected. The methylation status of IL-6 was determined by methylation specific polymerase chain reaction (MSP). The IL-6 expression was detected by real-time PCR. Correlations between IL-6 methylation status and clinical features or laboratory findings in patients with SLE were investigated.

Results: The methylation status and expression of IL-6 in peripheral blood could reflect the level in peripheral blood mononucleated cells (PBMCs) of SLE. Significantly positive correlation was found between IL-6 hypomethylation and renal disorder. Interleukin 6 hypomethylation was found negatively correlated with serum C3.

Conclusions: The detection of IL-6 methylation status in peripheral blood could reflect the status in PBMC with SLE. Interleukin 6 may play a role in renal disorder with SLE patients. Interleukin 6 could be considered as a new biomarker for predicting SLE flare.
keywords:

systemic lupus erythematosus, hypomethylation, interleukin-6, peripheral blood

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