Clinical immunology<br>Mucosal interleukin-21 mRNA expression level is high in patients with <i>Helicobacter pylori</i> and is associated with the severity 
of gastritis

Nader Bagheri; Fatemeh Azadegan-Dehkordi; Mahsa Shirzad; Benham Zamanzad; Ghorbanali Rahimian; Afshin Taghikhani; Mahmoud Rafieian-Kopaei; Hedayatollah Shirzad

doi:10.5114/ceji.2015.50835

eISSN: 1644-4124
ISSN: 1426-3912

Central European Journal of Immunology

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abstract:

Clinical immunology
Mucosal interleukin-21 mRNA expression level is high in patients with Helicobacter pylori and is associated with the severity of gastritis

Nader Bagheri

,

Fatemeh Azadegan-Dehkordi

,

Mahsa Shirzad

,

Benham Zamanzad

,

Ghorbanali Rahimian

,

Afshin Taghikhani

,

Mahmoud Rafieian-Kopaei

,

Hedayatollah Shirzad

(Centr Eur Immunol 2015; 40 (1): 61-67)

DOI: https://doi.org/10.5114/ceji.2015.50835

Online publish date: 2015/04/22

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AMA

Bagheri N, Azadegan-Dehkordi F, Shirzad M, et al. Clinical immunologyMucosal interleukin-21 mRNA expression level is high in patients with Helicobacter pylori and is associated with the severity 
of gastritis. Central European Journal of Immunology. 2015;40(1):61-67. doi:10.5114/ceji.2015.50835.

APA

Bagheri, N., Azadegan-Dehkordi, F., Shirzad, M., Zamanzad, B., Rahimian, G.,  & Taghikhani, A. et al. (2015). Clinical immunologyMucosal interleukin-21 mRNA expression level is high in patients with Helicobacter pylori and is associated with the severity 
of gastritis. Central European Journal of Immunology, 40(1), 61-67. https://doi.org/10.5114/ceji.2015.50835

Chicago

Bagheri, Nader, Fatemeh Azadegan-Dehkordi, Mahsa Shirzad, Benham Zamanzad, Ghorbanali Rahimian, Afshin Taghikhani,  and Mahmoud Rafieian-Kopaei et al. 2015. "Clinical immunologyMucosal interleukin-21 mRNA expression level is high in patients with Helicobacter pylori and is associated with the severity 
of gastritis". Central European Journal of Immunology 40 (1): 61-67. doi:10.5114/ceji.2015.50835.

Harvard

Bagheri, N., Azadegan-Dehkordi, F., Shirzad, M., Zamanzad, B., Rahimian, G., Taghikhani, A., Rafieian-Kopaei, M.,  and Shirzad, H. (2015). Clinical immunologyMucosal interleukin-21 mRNA expression level is high in patients with Helicobacter pylori and is associated with the severity 
of gastritis. Central European Journal of Immunology, 40(1), pp.61-67. https://doi.org/10.5114/ceji.2015.50835

MLA

Bagheri, Nader et al. "Clinical immunologyMucosal interleukin-21 mRNA expression level is high in patients with Helicobacter pylori and is associated with the severity 
of gastritis." Central European Journal of Immunology, vol. 40, no. 1, 2015, pp. 61-67. doi:10.5114/ceji.2015.50835.

Vancouver

Bagheri N, Azadegan-Dehkordi F, Shirzad M, Zamanzad B, Rahimian G, Taghikhani A et al. Clinical immunologyMucosal interleukin-21 mRNA expression level is high in patients with Helicobacter pylori and is associated with the severity 
of gastritis. Central European Journal of Immunology. 2015;40(1):61-67. doi:10.5114/ceji.2015.50835.

PlumX metrics:

Helicobacter pylori (H. pylori) infection is associated with gastritis and marked infiltration of the gastric mucosa by several cytokines secreting inflammatory cells. Different clinical forms of the infection may reflect distinctive patterns of cytokine expression. Interleukin (IL)-17, IL-21, IL-22, and IL-23 have been reported to be involved in H. pylori-induced gastric mucosal inflammation, but the details and relationship to different patterns of inflammation and virulence factors remain unclear. The present study was launched to analyse IL-6 expression in H. pylori-infected and uninfected gastric patients and to investigate its correlation with chronic gastritis among H. pylori-infected patients. Total RNA was extracted from the gastric antrum biopsies of 48 H. pylori-infected patients and 38 H. pylori uninfected patients. Mucosal IL-21 mRNA expression level in H. pylori-infected and uninfected gastric biopsy was determined by real-time PCR. The presence of vacA (vacuolating cytotoxin A) and cagA (cytotoxin associated gene A) virulence factors were evaluated using PCR. Interleukin-21 mRNA expression was significantly high in biopsies of H. pylori-infected patients compared to H. pylori uninfected patients, and the mucosal IL-21 mRNA level was positively correlated with the grade of chronic inflammation. There was no association between virulence factors and IL-21 mRNA expression. We believe that IL-21 might be involved in the pathogenesis of H. pylori and might be an index of the severity of chronic gastritis.

keywords:

Clinical immunologyMucosal interleukin-21 mRNA expression level is high in patients with Helicobacter pylori and is associated with the severity of gastritis

Nader Bagheri , Fatemeh Azadegan-Dehkordi , Mahsa Shirzad , Benham Zamanzad , Ghorbanali Rahimian , Afshin Taghikhani , Mahmoud Rafieian-Kopaei , Hedayatollah Shirzad

Helicobacter pylori, gastritis, IL-21, virulence factors

Clinical immunology
Mucosal interleukin-21 mRNA expression level is high in patients with Helicobacter pylori and is associated with the severity of gastritis

Nader Bagheri

,

Fatemeh Azadegan-Dehkordi

,

Mahsa Shirzad

,

Benham Zamanzad

,

Ghorbanali Rahimian

,

Afshin Taghikhani

,

Mahmoud Rafieian-Kopaei

,

Hedayatollah Shirzad