eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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4/2012
vol. 37
 
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abstract:

Clinical immunology
Original treatment methods of frequently recurrent chronic herpetic infection caused by herpes virus type 1 and type 2

Borys Herasun
,
Roman Hrytsko

(Centr Eur J Immunol 2012; 37 (4): 362-364)
DOI: https://doi.org/10.5114/ceji.2012.32726
Online publish date: 2013/02/10
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In the article we presented the results of clinical probation of new method of treatment of repeatedly recrudescent herpes simplex virus infection caused by types 1 and 2. Method of intradermal immunization with autoleukocytes was used in treatment of 32 patients (21 with herpes labialis and 11 with herpes genitalis) with frequent relapses – no less than 2-3 relapses a month during last 6 months (previous treatment with antiviral agents and immunostimulating/immunomodulating preparations failed). Leukocytes for immunization were isolated by sedimentation of heparinized blood at the temperature 37oC during 90-140 min. Blood plasma was centrifugated, then precipitated leukocytes were washed in cooled 0.9% NaCl solution. Leukocytes (in concentration 10-15 × 106 cells/ml) were injected with syringe intradermally in 10-12 skin sites of back between scapulas.

Stable remission occurred in 80.95% of patients with herpes labialis (in 17 of 21 patients) and 72.73% of patients with herpes genitalis (in 8 of 11 patients). Duration of surveillance was 3 years.

Effectiveness of treatment was a result of combined effects of leukocytes injected intradermally on the lymphocyte mediated immune response. Virus-containing autoleukocytes increase antiviral surveillance causing in leukocytes generation immune response (suppression or cytotoxicity) directed on themselves. This method is recommended for treatment of patients with repeatedly recrudescent herpes simplex virus infection with antiviral treatment failure.
keywords:

recurrent chronic herpetic infection caused by herpes simplex virus types 1 and 2, treatment of recurrent chronic herpetic infection, herpes-containing autoreactive cells, vaccination

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