Clinical immunology<br>Pro-inflammatory cytokines for evaluation of inflammatory status in endometriosis

Andrei M. Malutan; Tudor Drugan; Nicolae Costin; Razvan Ciortea; Carmen Bucuri; Maria P. Rada; Dan Mihu

doi:10.5114/ceji.2015.50840

eISSN: 1644-4124
ISSN: 1426-3912

Central European Journal of Immunology

Current issue Archive Manuscripts accepted About the journal Special Issues Editorial board Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures

Editorial System

Submit your Manuscript

1/2015
vol. 40

Send email

Copy url:

abstract:

Clinical immunology
Pro-inflammatory cytokines for evaluation of inflammatory status in endometriosis

Andrei M. Malutan

,

Tudor Drugan

,

Nicolae Costin

,

Razvan Ciortea

,

Carmen Bucuri

,

Maria P. Rada

,

Dan Mihu

(Centr Eur J Immunol 2015; 40 (1): 96-102)

DOI: https://doi.org/10.5114/ceji.2015.50840

Online publish date: 2015/04/22

View full text Get citation

PlumX metrics:

The aim of the study was to investigate the serum pro-inflammatory cytokine profile in patients with diagnosed endometriosis.

Material and methods: The study included 160 women, who were divided in two study groups (Group I – endometriosis; Group 2 – healthy). We evaluated the serum levels of interleukin (IL)-1β, IL-5, IL-6, IL-7, and IL-12, and of tumour necrosis factor α (TNF-α) with the use of Human Multiplex Cytokine Panels.

Results: The serum level of IL-1β, IL-6, and TNF-α is significantly higher in women with endometriosis compared to women free of disease, from the control group (mean 10.777, 183.027, and 131.326, respectively, compared to 3.039, 70.043, and 75.285, respectively; p = 0.002, p < 0.001, and p = 0.015, respectively). No significant differences in the serum levels of IL-5 and IL-12 were observed between the studied groups, and IL-7 had a very low detection rate.

Conclusions: Women with endometriosis have elevated levels of key pro-inflammatory cytokines, i.e. IL-1β, IL-6, and TNF-α. At the same time, IL-1β and IL-6 could be used as predictors for endometriosis.

keywords:

Clinical immunologyPro-inflammatory cytokines for evaluation of inflammatory status in endometriosis

Andrei M. Malutan , Tudor Drugan , Nicolae Costin , Razvan Ciortea , Carmen Bucuri , Maria P. Rada , Dan Mihu

inflammation, endometriosis, cytokine, interleukin

Clinical immunology
Pro-inflammatory cytokines for evaluation of inflammatory status in endometriosis

Andrei M. Malutan

,

Tudor Drugan

,

Nicolae Costin

,

Razvan Ciortea

,

Carmen Bucuri

,

Maria P. Rada

,

Dan Mihu