eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
Current issue Archive Manuscripts accepted About the journal Abstracting and indexing Subscription Contact Instructions for authors
SCImago Journal & Country Rank

4/2014
vol. 39
 
Share:
Share:
more
 
 
abstract:

Clinical immunology
Receptor activator of NF-kappaB ligand (RANKL) and CD 31 expressions in chronic periodontitis patients before and after surgery

Anton Friedmann
,
Nurdan Ozmeric
,
Jean-Pierre Bernimoulin
,
Bernd-Michael Kleber
,
Eylem Ayhan
,
Tuba Aykan
,
Ceren Gökmenoǧlu

(Centr Eur J Immunol 2014; 39 (4): 508-517)
Online publish date: 2014/12/15
View full text
Get citation
ENW
EndNote
BIB
JabRef, Mendeley
RIS
Papers, Reference Manager, RefWorks, Zotero
AMA
APA
Chicago
Harvard
MLA
Vancouver
 
Aim of the study: The present study investigated the hypothesis that upregulation of receptor activator of NF-kappaB ligand (RANKL) expression may be associated with upregulation of endothelial cell activitiy, which is common for periods of periodontal bone loss in chronic periodontitis.

Material and methods: RANKL expression of activated cells in soft tissue biopsies with CD 31 activity and the presence of RANKL and osteoprotegerin (OPG) in gingival crevicular fluid (GCF) were assessed in chronic periodontitis patients. Biopsies from 17 patients and 10 healthy subjects were immunohistochemically analyzed. Clinical measurements [plaque index (PI), the gingival index (GI), probing pocket depth (PPD), clinical attachment level (CAL) and gingival bleeding index (GBI)] and GCF samples were obtained before and after periodontal therapy.

Results: CD31 staining did not support the assumption that endothelium-like cells were predominantly associated with RANKL expression.

Conclusions: RANKL-positive cells were widely distributed in periodontitis patients giving only

partial support to the hypothesis that RANKL expression is restricted to T- and B-cell activation.
keywords:

gingival crevicular fluid, chronic periodontitis, immunohistochemistry, RANKL, CD31, osteoprotegerin

FEATURED PRODUCTS
Quick links
© 2019 Termedia Sp. z o.o. All rights reserved.
Developed by Bentus.
PayU - płatności internetowe