Clinical immunology<br>Receptor activator of NF-kappaB ligand (RANKL) and CD 31 expressions in chronic periodontitis patients before and after surgery

Anton Friedmann; Nurdan Ozmeric; Jean-Pierre Bernimoulin; Bernd-Michael Kleber; Eylem Ayhan; Tuba Aykan; Ceren Gökmenoǧlu

doi:10.5114/ceji.2014.47737

eISSN: 1644-4124
ISSN: 1426-3912

Central European Journal of Immunology

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abstract:

Clinical immunology
Receptor activator of NF-kappaB ligand (RANKL) and CD 31 expressions in chronic periodontitis patients before and after surgery

Anton Friedmann

,

Nurdan Ozmeric

,

Jean-Pierre Bernimoulin

,

Bernd-Michael Kleber

,

Eylem Ayhan

,

Tuba Aykan

,

Ceren Gökmenoǧlu

(Centr Eur J Immunol 2014; 39 (4): 508-517)

DOI: https://doi.org/10.5114/ceji.2014.47737

Online publish date: 2014/12/15

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AMA

Friedmann A, Ozmeric N, Bernimoulin J, et al. Clinical immunologyReceptor activator of NF-kappaB ligand (RANKL) and CD 31 expressions in chronic periodontitis patients before and after surgery. Central European Journal of Immunology. 2014;39(4):508-517. doi:10.5114/ceji.2014.47737.

APA

Friedmann, A., Ozmeric, N., Bernimoulin, J., Kleber, B., Ayhan, E.,  & Aykan, T. et al. (2014). Clinical immunologyReceptor activator of NF-kappaB ligand (RANKL) and CD 31 expressions in chronic periodontitis patients before and after surgery. Central European Journal of Immunology, 39(4), 508-517. https://doi.org/10.5114/ceji.2014.47737

Chicago

Friedmann, Anton, Nurdan Ozmeric, Jean-Pierre Bernimoulin, Bernd-Michael Kleber, Eylem Ayhan, Tuba Aykan,  and Ceren Gökmenoǧlu. 2014. "Clinical immunologyReceptor activator of NF-kappaB ligand (RANKL) and CD 31 expressions in chronic periodontitis patients before and after surgery". Central European Journal of Immunology 39 (4): 508-517. doi:10.5114/ceji.2014.47737.

Harvard

Friedmann, A., Ozmeric, N., Bernimoulin, J., Kleber, B., Ayhan, E., Aykan, T.,  and Gökmenoǧlu, C. (2014). Clinical immunologyReceptor activator of NF-kappaB ligand (RANKL) and CD 31 expressions in chronic periodontitis patients before and after surgery. Central European Journal of Immunology, 39(4), pp.508-517. https://doi.org/10.5114/ceji.2014.47737

MLA

Friedmann, Anton et al. "Clinical immunologyReceptor activator of NF-kappaB ligand (RANKL) and CD 31 expressions in chronic periodontitis patients before and after surgery." Central European Journal of Immunology, vol. 39, no. 4, 2014, pp. 508-517. doi:10.5114/ceji.2014.47737.

Vancouver

Friedmann A, Ozmeric N, Bernimoulin J, Kleber B, Ayhan E, Aykan T et al. Clinical immunologyReceptor activator of NF-kappaB ligand (RANKL) and CD 31 expressions in chronic periodontitis patients before and after surgery. Central European Journal of Immunology. 2014;39(4):508-517. doi:10.5114/ceji.2014.47737.

PlumX metrics:

Aim of the study: The present study investigated the hypothesis that upregulation of receptor activator of NF-kappaB ligand (RANKL) expression may be associated with upregulation of endothelial cell activitiy, which is common for periods of periodontal bone loss in chronic periodontitis.

Material and methods: RANKL expression of activated cells in soft tissue biopsies with CD 31 activity and the presence of RANKL and osteoprotegerin (OPG) in gingival crevicular fluid (GCF) were assessed in chronic periodontitis patients. Biopsies from 17 patients and 10 healthy subjects were immunohistochemically analyzed. Clinical measurements [plaque index (PI), the gingival index (GI), probing pocket depth (PPD), clinical attachment level (CAL) and gingival bleeding index (GBI)] and GCF samples were obtained before and after periodontal therapy.

Results: CD31 staining did not support the assumption that endothelium-like cells were predominantly associated with RANKL expression.

Conclusions: RANKL-positive cells were widely distributed in periodontitis patients giving only

partial support to the hypothesis that RANKL expression is restricted to T- and B-cell activation.

keywords:

Clinical immunologyReceptor activator of NF-kappaB ligand (RANKL) and CD 31 expressions in chronic periodontitis patients before and after surgery

Anton Friedmann , Nurdan Ozmeric , Jean-Pierre Bernimoulin , Bernd-Michael Kleber , Eylem Ayhan , Tuba Aykan , Ceren Gökmenoǧlu

gingival crevicular fluid, chronic periodontitis, immunohistochemistry, RANKL, CD31, osteoprotegerin

Clinical immunology
Receptor activator of NF-kappaB ligand (RANKL) and CD 31 expressions in chronic periodontitis patients before and after surgery

Anton Friedmann

,

Nurdan Ozmeric

,

Jean-Pierre Bernimoulin

,

Bernd-Michael Kleber

,

Eylem Ayhan

,

Tuba Aykan

,

Ceren Gökmenoǧlu