eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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vol. 39

Clinical immunology
The effects of calcitriol with calcium carbonate supplementation on inflammatory biomarkers in chronic kidney disease patients’ with low vitamin D

Ruslinda BT Mustafar
Rozita Mohd
Norazinizah Ahmad Miswan
Arba’ayah Bain
Rizna Cader
Abdul Halim Abdul Gafor
Marlyn Mohammad
Shamsul Azhar Shah
Nor Azmi Kamaruddin
Norella CT Kong

(Centr Eur J Immunol 2014; 39 (2): 236–242)
Online publish date: 2014/06/27
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Introduction: Chronic kidney disease (CKD) patients’ are at risk of low vitamin D and chronic inflammation. We studied the effect of 12 weeks calcitriol and calcium carbonate supplementation on inflammatory mediators serum; interleukin-6 (IL-6), interleukin-10 (IL-10) and highly sensitive C-reactive protein (hs-CRP).

Material and methods: A prospective randomized study in CKD stages 2-4 with serum 25-hydroxyvitamin D (25-OHD) levels < 30 ng/ml. Patients were randomized into the Vitamin D + Calcium (Vitamin D+C) or Calcium group. Serums were analyzed at baseline, week 6 and 12.

Results: Fifty patients, median age of 53 (13.5) years were recruited. Their median IL-10 was 13.35 (25.22) pg/ml. At week 12, serum IL-6 was reduced in both groups (p = 0.001), serum IL-10 was maintained in the Vitamin D + C group (p = 0.06) and was reduced in the Calcium group (p = 0.001). CKD-diabetic patients had reduced serum IL-6 in both study groups (p = 0.001) and a reduction was seen in the Vitamin D + C group of the non-diabetics counterparts (p = 0.005). Serum IL-10 was reduced in the Calcium group (p < 0.05) whereas serum 25-OHD rose in both groups, regardless of their diabetic status (p < 0.05).

Conclusions: Twelve weeks, calcitriol supplementation maintained IL-10, had no effects on hs-CRP and had no additional benefit compared to calcium carbonate in reducing serum IL-6 except in non-diabetics.

inflammation, vitamin D, diabetes, chronic kidney disease, calcitriol

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