eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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4/2014
vol. 39
 
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abstract:

Clinical immunology
Vitamin D deficiency is related to thyroid antibodies in autoimmune thyroiditis

Aslı Dogruk Unal
,
Ozlem Tarcin
,
Hulya Parildar
,
Ozlem Cigerli
,
Hacer Eroglu
,
Nilgun Guvener Demirag

(Centr Eur J Immunol 2014; 39 (4): 493-497)
Online publish date: 2014/12/15
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Introduction: It has been known that vitamin D has some immunomodulatory effects and in autoimmune thyroid diseases, vitamin D deficiency was more prevalent. In this study, our aim was to investigate the relationship between thyroid autoantibodies and vitamin D.

Material and methods: Group 1 and 2 consisted of 254 and 27 newly diagnosed Hashimoto’s thyroiditis (HT) and Graves’ disease (GD) cases, respectively; age-matched 124 healthy subjects were enrolled as controls (group 3). All subjects (n = 405) were evaluated for 25OHD and thyroid autoantibody [anti-thyroid peroxidase (anti-TPO) and anti-thyroglobulin (anti-tg)] levels.

Results: Group 2 and group 1 patients had lower 25OHD levels than group 3 subjects 14.9 ±8.6 ng/ml, 19.4 ±10.1 ng/ml and 22.5 ±15.4 ng/ml, respectively (p < 0.001). Serum 25OHD levels inversely correlated with anti-tg (r = –0.136, p = 0.025), anti-TPO (r = –0.176, p = 0.003) and parathormone (PTH) (r = –0.240, p < 0.001). Group 2 patients had higher anti-tg and anti-TPO levels than group 1 and 3 (p < 0.001).

Conclusions: In this study, we found that patients with autoimmune thyroid disease (AITD) present with lower vitamin D levels and GD patients have higher prevalence. Since we found an inverse correlation between vitamin D levels and thyroid antibody levels, we may suggest that vitamin D deficiency is one of the potential factors in pathogenesis of autoimmune thyroid disorders.
keywords:

vitamin D, thyroid, autoimmunity

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